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Enterococci facilitate polymicrobial infections.

Wenjiao Xu1, Yuwen Fang1, Kui Zhu1

  • 1National Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China; Engineering Research Center of Animal Innovative Drugs and Safety Evaluation, Ministry of Education, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.

Trends in Microbiology
|August 7, 2023
PubMed
Summary

Enterococci, often overlooked pathobionts, significantly drive polymicrobial infections by promoting pathogen growth and reducing drug efficacy. New therapies targeting enterococci are crucial for public health.

Keywords:
enterococcioutgrowthpathobiontpathogenesispolymicrobial infectionstherapeutic strategies

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Area of Science:

  • Microbiology
  • Infectious Diseases
  • Pathogen Interactions

Background:

  • Enterococci are common gut microbes and significant nosocomial pathogens.
  • They act as pathobionts, playing key roles in polymicrobial infections.
  • Enterococci can enhance pathogen persistence and reduce treatment effectiveness.

Purpose of the Study:

  • To review the role of enterococci in polymicrobial infections.
  • To explore mechanisms of enterococci-mediated pathogenesis.
  • To discuss novel therapeutic strategies against these infections.

Main Methods:

  • Literature review of enterococci in polymicrobial infections.
  • Analysis of factors influencing enterococci outgrowth.
  • Examination of enterococci-associated infection sites and types.

Main Results:

  • Enterococci facilitate colonization and pathogenesis of other microbes.
  • They compromise antimicrobial drug efficacy, posing public health risks.
  • Current treatments often neglect the critical role of enterococci.

Conclusions:

  • Understanding enterococci's role is vital for treating polymicrobial infections.
  • Targeting enterococci offers a promising avenue for new therapies.
  • Further research into intervention strategies is needed.