Leiomyomatous hemangiomas of the liver mimicking primary leiomyomas

We present a case of multiple, benign, smooth-muscle tumors of the liver discovered at autopsy. Although these tumors appeared at first to be primary leiomyomas, rare neoplasms in the liver, the presence of leiomyomas in other organs precluded this diagnosis. Since typical cavernous hemangiomas were also present in the liver, we interpreted the smooth-muscle tumors to be leiomyomatous hemangiomas. Staining with immunoperoxidase for factor VIII-related antigen supported this diagnosis.