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Gut microbial genetic variation modulates host lifespan, sleep, and motor performance
Ying Li1, Simin Xu2, Liying Wang3
1Medical Technology College, Xuzhou Medical University, Xuzhou, China.
The ISME Journal
|August 7, 2023
Summary
Gut microbes influence host lifespan and activities. Yeast genes, like catalase A, impact fruit fly sleep and longevity by modulating oxidative stress, revealing microbial genetic links to host health.
Area of Science:
- Microbiology
- Genetics
- Aging Research
Background:
- Gut microorganisms influence host phenotypes like lifespan and sleep.
- The specific role of gut microbial genetic variation in these processes is not well understood.
Purpose of the Study:
- To investigate the connection between gut microbial genetic variation and host phenotypes.
- To explore the function of yeast peroxisome-related genes in modulating host health and longevity.
Main Methods:
- Utilized Saccharomyces cerevisiae (yeast) and Drosophila melanogaster (fruit flies) as model organisms.
- Examined the impact of specific yeast gene deficiencies (e.g., catalase A) on fruit fly lifespan and sleep.
- Analyzed the relationship between sleep parameters and lifespan in a large cohort, controlling for genetic background.
Main Results:
- Yeast peroxisome-related genes play a role in regulating host lifespan and activities via oxidative stress modulation.
- Deficiency in yeast catalase A (CTA1) significantly reduced fruit fly sleep duration and lifespan.
- Lifespan was positively associated with sleep duration, independent of sleep fragmentation or motor performance.
Conclusions:
- Gut microbial genetic variation, particularly involving peroxisome-related genes, can significantly impact host phenotypes.
- Catalase A in gut microbes is a key factor influencing host longevity and sleep.
- This research provides new insights into the gut-microbe-host axis and its implications for health and longevity.
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