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Updated: Jul 19, 2025

Chemical Reversion of Conventional Human Pluripotent Stem Cells to a Naïve-like State with Improved Multilineage Differentiation Potency
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Chemical Reversion of Conventional Human Pluripotent Stem Cells to a Naïve-like State with Improved Multilineage Differentiation Potency

Published on: June 10, 2018

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A fast chemical reprogramming system promotes cell identity transition through a diapause-like state

Xi Chen1, Yunkun Lu1, Leyun Wang2,3

  • 1The Second Affiliated Hospital and Life Sciences Institute and School of Medicine, The MOE Key Laboratory of Biosystems Homeostasis and Protection and Zhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology, Zhejiang University, Hangzhou, China.

Nature Cell Biology
|August 7, 2023
PubMed
Summary

We developed a fast chemical reprogramming (FCR) system using small molecules to accelerate cell identity rewiring for regenerative medicine. This method rapidly induces pluripotency, offering new insights into cellular regeneration.

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