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Updated: Jul 19, 2025

Point of Care Transcranial Color-Coded Duplex Ultrasound of the Middle Cerebral Artery
04:01

Point of Care Transcranial Color-Coded Duplex Ultrasound of the Middle Cerebral Artery

Published on: August 9, 2024

773

Clinical, radiological profile and prognostic role of transcranial color-coded duplex in cerebral venous thrombosis:

Alshaimaa M Aboul Fotouh1, Sadek Mohamed Helmy1, Husam S Mourad1

  • 1Department of Neurology, Faculty of medicine, Cairo University, Al-Saraya Street, Al Manial, Cairo, Egypt.

BMC Neurology
|August 7, 2023
PubMed

Insights

Cerebral venous thrombosis (CVT) in Egyptian patients presents variably, with female predominance and genetic factors like Factor V Leiden mutation being common. Transcranial color-coded duplex ultrasound shows altered venous flow, reflecting the condition's hemodynamic state.

Area of Science:

  • Neurology
  • Vascular Medicine
  • Diagnostic Imaging

Background:

  • Cerebral venous thrombosis (CVT) is a rare stroke subtype, disproportionately affecting younger individuals.
  • Variable clinical presentations of CVT can lead to diagnostic delays and impact patient outcomes.
  • Understanding CVT's profile in specific populations is crucial for timely diagnosis and management.

Purpose of the Study:

  • To investigate the clinical and radiological characteristics of cerebral venous thrombosis (CVT) in Egyptian patients.
  • To identify prevalent risk factors, including genetic thrombophilias, associated with CVT.
  • To evaluate the utility of transcranial color-coded duplex (TCCD) in assessing CVT prognosis.

Main Methods:

  • A case-control study involving 80 CVT patients and 80 healthy controls.
  • Diagnostic tools included magnetic resonance imaging (MRI), magnetic resonance venography (MRV), and genetic thrombophilia testing.
  • Transcranial color-coded duplex (TCCD) was used to assess the deep cerebral venous system in both groups.

Main Results:

  • Female predominance observed, with gender-specific risk factors being the most common etiology.
  • Homozygous Factor V Leiden mutation and anti-thrombin III deficiency were the most frequent hereditary thrombophilias.
  • Headache was the most common symptom; transverse sinus thrombosis occurred in 43 patients. TCCD revealed increased flow velocities in the deep cerebral venous system of CVT patients.

Conclusions:

  • CVT exhibits highly variable clinical presentations.
  • Homozygous Factor V Leiden mutation and AT III deficiency are significant risk factors in the studied Egyptian population.
  • Elevated deep cerebral venous system flow velocities detected by TCCD correlate with the venous hemodynamic state in CVT.
Abstract

Keywords:
Cerebral venous thrombosisHereditary thrombophiliaTranscranial color-coded duplexVenous velocities

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