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Association between periodontitis and temporomandibular joint disorders
Shaotai Wang1,2, Huan Jiang3,4, Huichuan Qi1,2
1Department of Orthodontics, Hospital of Stomatology, Jilin University, Changchun, 130021, China.
Arthritis Research & Therapy
|August 7, 2023
Summary
This study found no causal link between periodontitis (PD) and temporomandibular joint disorders (TMD). Mendelian randomization analysis indicates neither condition directly causes the other, clarifying their relationship.
Area of Science:
- Investigates the complex interplay between oral health and temporomandibular joint function.
- Utilizes advanced genetic epidemiology techniques to explore disease causality.
Background:
- Previous observational studies suggested bidirectional associations between periodontitis (PD) and temporomandibular joint disorders (TMD).
- These studies were limited by potential confounders and reverse causation, hindering definitive conclusions on causality.
- This research aims to clarify the causal relationship between PD and TMD using a robust methodology.
Approach:
- Employed a bidirectional two-sample Mendelian randomization (MR) analysis.
- Utilized genome-wide association study (GWAS) data from multiple large consortia (GLIDE, FinnGen, UK Biobank).
- Applied various MR methods (IVW, WM, MR-Egger, MR-PRESSO) and sensitivity analyses to ensure reliable estimations.
Key Points:
- Mendelian randomization analysis revealed no evidence of a causal effect of periodontitis (PD) on temporomandibular joint disorders (TMD).
- Conversely, the analysis also found no significant causal effect of TMD on PD.
- Sensitivity analyses confirmed the robustness of the findings, ruling out significant pleiotropy.
Conclusions:
- This study does not support a causal relationship between periodontitis and temporomandibular joint disorders.
- Findings suggest that neither PD nor TMD directly causes or exacerbates the other condition.
- The results provide a clearer understanding of the non-causal association between these two health conditions.
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