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Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation
Published on: January 26, 2016
Cyclic Peptides from the Opportunistic Pathogen Basidiobolus meristosporus
Cheng Zhao1, Jiaojiao Qu1, Fan Peng1
1Engineering Research Center of Fungal Biotechnology, Ministry of Education; Research Center on Entomogenous Fungi, Anhui Agricultural University, Hefei, Anhui Province 230036, People's Republic of China.
Abstract:
Three new cyclic peptides, meristosporins A, B, and C (1-3), one of which features an unusual amino acid, were isolated from the opportunistic pathogen and identified by 1D, 2D NMR, MS/MS, and Marfey's analysis. The biosynthetic pathway of the hexapeptide meristosporin A (1) was deduced based on nonribosomal peptide synthetase gene clusters analysis. Compounds 1 and 2 showed cytotoxicity to RAW264.7 and 293T cells, respectively. These compounds may be involved in the fungal injury caused to human cells.
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