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Updated: Jul 30, 2026

Metabolic Glycoengineering of Sialic Acid Using N-acyl-modified Mannosamines
Published on: November 25, 2017
Sialic acid: an attractive biomarker with promising biomedical applications
Aida Doostkam1, Leila Malekmakan1, Alireza Hosseinpour2
1Shiraz Nephro-Urology Research Center, Shiraz University of Medical Sciences, Shiraz 7193635899, Iran.
Abstract:
This broad, narrative review highlights the roles of sialic acids as acidic sugars found on cellular membranes. The role of sialic acids in cellular communication and development has been well established. Recently, attention has turned to the fundamental role of sialic acids in many diseases, including viral infections, cardiovascular diseases, neurological disorders, diabetic nephropathy, and malignancies. Sialic acid may be a target for developing new drugs to treat various cancers and inflammatory processes. We recommend the routine measurement of serum sialic acid as a sensitive inflammatory marker in various diseases.
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