Related Experiment Video
Updated: Jul 31, 2026
07:49
Evaluation of Tumor-infiltrating Leukocyte Subsets in a Subcutaneous Tumor Model
Published on: April 13, 2015
20.2K
Is Chemerin Associated with Gestational Diabetes Mellitus? A Case-Control Study
Ziwen Ma1, Liming Chu1, Yan Zhang1
1Department of Obstetrics and Gynecology, Shanghai Pudong New Area Healthcare Hospital for Women and Children, Shanghai, People's Republic of China.
Summary
Elevated chemerin levels are linked to gestational diabetes mellitus (GDM) risk. The placenta, along with adipose tissue, may contribute to GDM development.
Area of Science:
- Endocrinology
- Metabolic Disorders
- Pregnancy Complications
Background:
- Gestational diabetes mellitus (GDM) is a common pregnancy complication.
- Chemerin, a adipokine, has been implicated in metabolic disorders.
- Understanding chemerin's role in GDM is crucial for early detection and management.
Purpose of the Study:
- To investigate the relationship between GDM and chemerin.
- To analyze chemerin levels in maternal and cord blood.
- To examine chemerin mRNA and protein expression in placental and adipose tissues.
Main Methods:
- A case-control study involving 110 women with GDM and 110 controls.
- Measurement of chemerin levels in peripheral and cord blood.
- Assessment of chemerin mRNA and protein expression in placental and adipose tissues.
Main Results:
- Women with GDM had higher pre-pregnancy BMI, TG/HDL ratio, and TG levels, and lower HDL levels.
- Chemerin levels were significantly higher in cord blood of the GDM group.
- Chemerin mRNA and protein expression were significantly elevated in the placenta and adipose tissue of GDM patients, correlating with GDM risk.
Conclusions:
- Elevated chemerin is closely associated with the risk of GDM.
- The placenta is identified as a potential significant source of chemerin in GDM, in addition to adipose tissue.
- These findings suggest chemerin's involvement in the pathogenesis of GDM.
Related Concept Videos
01:27Glucose Transporters
Glucose transporters facilitate the transport of glucose across the cell membrane. In addition to glucose, some glucose transporters can also aid the movement of other hexoses such as fructose, mannose, and galactose.
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
01:22Diabetes Mellitus: Type 2 and Gestational
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
01:20Pathophysiology of Diabetes
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility, suggesting a...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility, suggesting a...
01:26Diabetes Mellitus: Introduction
Diabetes mellitus consists of chronic metabolic disorders characterized by persistent hyperglycemia. This elevated blood glucose results from defects in insulin secretion, impaired insulin action, or both. Insulin, produced by pancreatic β-cells, is essential for maintaining glucose homeostasis by facilitating cellular glucose uptake for energy or storage. Disruptions in insulin production or function lead to glucose accumulation in the bloodstream, causing the clinical features and long-term...
01:19Type I Diabetes III: Clinical Manifestations
Type 1 diabetes mellitus typically presents with rapid-onset symptoms due to the body’s inability to utilize glucose in the absence of insulin. Since insulin is required for glucose uptake into cells, its deficiency leads to hyperglycemia and cellular energy deprivation, resulting in characteristic clinical features.Polyuria and PolydipsiaOne of the earliest, most prominent symptoms is polyuria (excessive urination). When blood glucose concentrations rise above the renal threshold, the kidneys...
01:29Hyperglycemia
Hyperglycemia is an abnormally high blood glucose level. It is diagnosed by fasting glucose ≥126 mg/dL, 2-hour oral glucose tolerance test (or OGTT) ≥200 mg/dL, random glucose ≥200 mg/dL with symptoms, or HbA1c ≥6.5%. However, HbA1c results may be unreliable in certain conditions, such as anemia or hemoglobinopathies, and the diagnosis should be confirmed unless classic symptoms are present. Postprandial hyperglycemia is typically considered significant when glucose levels exceed 180 mg/dL two...