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Updated: Jul 19, 2025
Multiplexed Fluorescent Immunohistochemical Staining, Imaging, and Analysis in Histological Samples of Lymphoma
Published on: January 9, 2019
[Analysis of Histologic Transformation and Prognosis for Follicular Lymphoma]
Tian-Jiao Zhao1, Duo Xu1, Xiao-Fei Chai1
1Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China.
Objective:
To investigate the related factors of invasive transformation and prognosis for follicular lymphoma.
Methods:
A total of 168 patients with follicular lymphoma at First Affiliated Hospital of Zhengzhou University from August 2015 to January 2021 were collected, and the significance of each index in histological transformation (HT) and prognosis were analyzed.
Results:
Pathology grade3, Ki-67 index ≥40%, β2MG＞3 mg/L, LDH＞245 U/L, POD24 and non-invasion of bone marrow were associated with HT. Univariate analysis showed that the high risk of FLIPI-2, pathological grade 3, Ki-67≥40%, anemia, β2MG＞3 mg/L, LDH＞245 U/L and HT had significant adverse effects on PFS; β2MG＞3 mg/L, LDH＞245 U/L, POD24 and HT had significant adverse effects on OS. Cox multivariate analysis showed that the β2MG >3 mg/L and HT were independent risk factors of PFS, HT was independent risk factor of OS.
Conclusion:
The pathological grade, Ki-67, β2MG, LDH, POD24 and bone marrow invasion of FL can predict the risk of HT. Meanwhile, β2MG >3 mg/L and HT are significantly related to poor prognosis of FL.
