[Delayed Blood Transfusion Adverse Reactions Caused by Hypothermia Cardiopulmonary Bypass and Its Coping Strategies]
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Updated: Jul 19, 2025

Establishment of Deep Hypothermic Circulatory Arrest in Rats
Published on: December 16, 2022
Jia-Dong Ding1, Yi-Yuan Wang1, Xiao-Ping Zhang2
1Department of Blood Transfusion, Gansu Provincial Hospital, Lanzhou 730000, Gansu Province, China.
Objective:
To investigate a case of delayed hemolytic transfusion reaction (DHTR), and find the reason and coping strategies to prevent similar incidents in the future.
Methods:
Relative antibody identification was carried out, suitable erythrocytes was screened, and relevant indicators after transfusion were evaluated. Medical record and laboratory report of the patient were reviewed, the cause was analyzed, and corresponding treatment was carried out.
Results:
The patient suffered from DHTR caused by IgM anti-M antibody and low body temperature cardiopulmonary bypass. After anti-hemolytic treatment, the patient was gradually improved, the bilirubin gradually decreased, and finally cured and discharged.
Conclusion:
When the transfusion department finds any antibodies which have activity at room temperature but no respond at 37 ℃, they should communicate with clinical medical staff in time. Warm transfusion should be used during blood transfusion to prevent transfusion-related hemolytic reaction.
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