Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Local Anesthetics: Clinical Application as Spinal Anesthesia01:11

Local Anesthetics: Clinical Application as Spinal Anesthesia

677
Spinal anesthetics are given during lower abdomen and limb surgeries to block sensory and motor neurons. They are administered in the mid to low lumbar regions, primarily acting on the cauda equina's nerve roots. The blockade level depends on the local anesthetic (LA) concentration. Usually, low LA concentrations are sufficient to block sensory fibers, while only high LA concentrations block motor fibers. Other factors like injection volume and speed, the patient's posture, and the drug...
677
Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia01:16

Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia

457
Intravenous regional anesthesia or the Bier block technique is used to anesthetize a specific limb or extremity. It uses exsanguinated or blood-drained vessels to transport local anesthetics or LAs to the peripheral nerve trunks. Lidocaine without vasoconstrictors like epinephrine is most commonly used for this technique. Other drugs used are prilocaine, ropivacaine, and chloroprocaine. Bupivacaine is not recommended for this technique due to its high cardiac toxicity.
One of the advantages of...
457
Skeletal Muscle Relaxants: Therapeutic Uses01:31

Skeletal Muscle Relaxants: Therapeutic Uses

514
Skeletal muscle relaxants are used to relax muscle tone and alleviate painful muscle contractions. However, the choice of skeletal muscle relaxants depends on the duration of the surgical procedure in order to minimize potential side effects. Skeletal muscle relaxants like neuromuscular blocking agents [NMBAs] are commonly employed as adjuvants alongside general anesthetics in clinical settings. NMBAs are also used to maintain controlled ventilation during surgery of the larynx or pharynx...
514
Nondepolarizing (Competitive) Neuromuscular Blockers: Pharmacological Actions01:27

Nondepolarizing (Competitive) Neuromuscular Blockers: Pharmacological Actions

457
Nondepolarizing neuromuscular blockers prevent the membrane depolarization of muscle cells and inhibit muscle contraction. These are usually administered with anesthetics to achieve complete muscle relaxation. Upon administration, these drugs first block the small, rapidly contracting muscles of the face and hands, followed by the larger muscles of the trunk and the intercostal muscles. The diaphragm is the last muscle to be affected.
Although all competitive neuromuscular blockers are designed...
457
Peripheral Artery Disease V: Postoperative Nursing Management01:23

Peripheral Artery Disease V: Postoperative Nursing Management

12
During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
12
Classification of Skeletal Muscle Relaxants01:28

Classification of Skeletal Muscle Relaxants

2.5K
Skeletal muscle relaxants are a group of drugs that can reduce muscle stiffness and induce temporary paralysis to relieve pain. These agents can act centrally to reduce muscle tone or spasms in painful conditions such as multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), or spinal injuries; they are called antispasmodics or spasmolytics.
Peripherally acting skeletal muscle relaxants interfere with the neurotransmission at the neuromuscular end plate to induce paralysis during...
2.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Discovery of Small-Molecule Antagonists of PHF1 and 19 Demonstrates the Ligandability of PRC2 Accessory Proteins.

ACS bio & med chem Au·2026
Same author

Selective degradation of TBK1 uncovers mechanistic insights into blocking ccRCC progression.

Cell chemical biology·2026
Same author

2026 American Society of Anesthesiologists Practice Guideline on Perioperative Pain Management Using Local and Regional Analgesia for Cardiothoracic Surgeries, Mastectomy, and Abdominal Surgeries.

Anesthesiology·2025
Same author

Prioritization of outcome measures in regional anesthesia research.

Regional anesthesia and pain medicine·2025
Same author

Tale of two approaches to ultrasound-guided interscalene brachial plexus block: a pro-con.

Regional anesthesia and pain medicine·2025
Same author

Limited evidence for anesthesia and analgesia for outpatient primary knee and hip arthroplasty: A scoping review.

Orthopaedics & traumatology, surgery & research : OTSR·2025

Related Experiment Video

Updated: Jul 19, 2025

Partial Sciatic Nerve Ligation: A Mouse Model of Chronic Neuropathic Pain to Study the Antinociceptive Effect of Novel Therapies
08:16

Partial Sciatic Nerve Ligation: A Mouse Model of Chronic Neuropathic Pain to Study the Antinociceptive Effect of Novel Therapies

Published on: October 6, 2022

6.4K

Motor-sparing peripheral nerve blocks for hip and knee surgery.

Mariana Restrepo-Holguin1, Sandra L Kopp, Rebecca L Johnson

  • 1Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota, USA.

Current Opinion in Anaesthesiology
|August 8, 2023
PubMed
Summary

Novel motor-sparing peripheral nerve blocks for hip and knee surgery preserve muscle function, enabling faster recovery and early physical therapy. These techniques offer adequate pain control with fewer opioid side effects for same-day discharge patients.

More Related Videos

Modified Spared Nerve Injury Surgery Model of Neuropathic Pain in Mice
04:34

Modified Spared Nerve Injury Surgery Model of Neuropathic Pain in Mice

Published on: January 25, 2022

4.9K
An Ultrasonic Tool for Nerve Conduction Block in Diabetic Rat Models
10:27

An Ultrasonic Tool for Nerve Conduction Block in Diabetic Rat Models

Published on: October 20, 2017

7.4K

Related Experiment Videos

Last Updated: Jul 19, 2025

Partial Sciatic Nerve Ligation: A Mouse Model of Chronic Neuropathic Pain to Study the Antinociceptive Effect of Novel Therapies
08:16

Partial Sciatic Nerve Ligation: A Mouse Model of Chronic Neuropathic Pain to Study the Antinociceptive Effect of Novel Therapies

Published on: October 6, 2022

6.4K
Modified Spared Nerve Injury Surgery Model of Neuropathic Pain in Mice
04:34

Modified Spared Nerve Injury Surgery Model of Neuropathic Pain in Mice

Published on: January 25, 2022

4.9K
An Ultrasonic Tool for Nerve Conduction Block in Diabetic Rat Models
10:27

An Ultrasonic Tool for Nerve Conduction Block in Diabetic Rat Models

Published on: October 20, 2017

7.4K

Area of Science:

  • Anesthesiology
  • Orthopedic Surgery
  • Pain Management

Background:

  • Increasing trend of same-day discharge for hip and knee surgeries necessitates preservation of lower extremity motor function.
  • Early physical therapy is crucial for patient recovery and successful outpatient ambulation after lower extremity procedures.
  • Motor-sparing peripheral nerve blocks are emerging as a key strategy to balance analgesia and functional recovery.

Approach:

  • Literature review summarizing novel motor-sparing peripheral nerve block techniques for hip and knee surgery.
  • Comparison of efficacy and safety profiles of different block techniques.
  • Analysis of outcomes related to motor strength, analgesia, and patient ambulation.

Key Points:

  • Distal peripheral nerve blocks show potential for preserved quadriceps motor strength and comparable analgesia to traditional methods.
  • Studies indicate that for hip surgeries, regional blocks and periarticular infiltration offer similar analgesic effects.
  • For knee arthroplasty, combining blocks like adductor canal block (ACB) with iPACK or genicular nerve blocks may optimize pain control and early ambulation.

Conclusions:

  • Motor-sparing peripheral nerve blocks facilitate early ambulation, effective pain management, and reduced opioid use, supporting ambulatory lower extremity surgery.
  • Further research is required to evaluate the long-term benefits of continuous peripheral nerve block catheters in maintaining motor-sparing and opioid-sparing effects.
  • These techniques are vital for enhancing patient recovery and enabling outpatient procedures in orthopedic surgery.