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Updated: Jul 19, 2025
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Author Spotlight: Advancements and Challenges in Surgical Treatments for Postamputation Pain
Published on: March 8, 2024
2.7K
Chronic post amputation pain: pathophysiology and prevention options for a heterogenous phenomenon
Alexander B Stone1, Markus W Hollmann2, Lotte E Terwindt2
1Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Current Opinion in Anaesthesiology
|August 8, 2023
Summary
Preventing chronic postamputation pain (cPAP) is crucial, but no definitive regimen exists. Research explores risk factors and novel interventions like neuromodulation for phantom limb pain management.
Area of Science:
- Neuroscience
- Pain Management
- Surgical Innovation
Background:
- Chronic postamputation pain (cPAP) presents a significant clinical challenge.
- Current strategies emphasize prevention due to treatment difficulties.
- No universally effective evidence-based prevention regimen is established.
Conclusions:
- Phantom limb pain results from complex peripheral and central nervous system changes interacting with patient-specific factors.
- Prevention is paramount due to treatment challenges.
- Further research is needed on evidence-based interventions, optimal timing, and patient stratification for personalized prevention.
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