Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pulmonary Cycle: Exhalation01:17

Pulmonary Cycle: Exhalation

1.6K
In terms of human respiration, the act of expelling air, known as exhalation (or expiration), operates on the principle of pressure gradients. During expiration, the pressure within the lungs exceeds that of the surrounding atmosphere. Under normal conditions, quiet breathing involves passive exhalation and is free of muscular contractions. This is because the exhalation process is driven by the natural elastic recoil of the lungs and chest wall, both of which have an inherent tendency to...
1.6K
Pneumothorax-II01:27

Pneumothorax-II

197
Pneumothorax is a medical condition defined by the buildup of air in the pleural space between the lungs and the chest wall. This accumulation of air can lead to partial or complete lung collapse, resulting in a range of clinical manifestations. Understanding the clinical presentation and effective management strategies is crucial for healthcare professionals in providing timely and appropriate care to individuals with pneumothorax.
Clinical Manifestations:
197
Breathing01:05

Breathing

59.6K
The process of breathing, inhaling and exhaling, involves the coordinated movement of the chest wall, the lungs, and the muscles that move them. Two muscle groups with important roles in breathing are the diaphragm, located directly below the lungs, and the intercostal muscles, which lie between the ribs. When the diaphragm contracts, it moves downward, increasing the volume of the thoracic cavity and creating more room for the lungs to expand. When the intercostal muscles contract, the ribs...
59.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Gender disparities in Italian academic medicine: A cross-sectional study of clinicians in the 2024 stanford top 2% scientists database.

PloS one·2026
Same author

The impact of CPR coach presence and position on team leader and team performance during asystole simulation scenario: a randomized simulation-based trial.

PloS one·2026
Same author

Erector spinae plane block for postoperative analgesia in vertebral surgery: an umbrella review of systematic reviews and meta-analyses.

The Korean journal of pain·2025
Same author

High-Flow Tracheal Oxygen for Tracheostomy Tube Removal in Lung Transplant Recipients.

Journal of clinical medicine·2023
Same author

Impact of self-citation on author h-index in anaesthesiology and pain medicine.

British journal of anaesthesia·2023
Same author

[The Pacemaker and Implantable Cardioverter-Defibrillator Registry of the Italian Association of Arrhythmology and Cardiac Pacing - Report 2022].

Giornale italiano di cardiologia (2006)·2023

Related Experiment Video

Updated: Jul 19, 2025

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation
10:01

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation

Published on: July 10, 2012

20.5K

Diaphragm Dysfunction Predicts Weaning Outcome after Bilateral Lung Transplant.

Annalisa Boscolo1, Nicolò Sella2, Tommaso Pettenuzzo2

  • 1Department of Medicine, and Thoracic Surgery and Lung Transplant Unit, Department of Cardiac, Thoracic, Vascular Sciences, and Public Health, University of Padua, Padua, Italy; Institute of Anesthesia and Intensive Care, Padua University Hospital, Padua, Italy.

Anesthesiology
|August 8, 2023
PubMed
Summary

Diaphragm dysfunction is common in bilateral-lung transplant recipients and linked to difficult ventilator weaning. Diaphragm thickening fraction and neuroventilatory efficiency predict weaning success and correlate inversely with ventilation duration.

More Related Videos

Donor Posterior Atrial Flap Rotation for Left Atrial Cuff Reconstruction in Lung Transplantation
07:28

Donor Posterior Atrial Flap Rotation for Left Atrial Cuff Reconstruction in Lung Transplantation

Published on: October 11, 2024

387
Author Spotlight: Investigating the Key Factors of Obliterative Bronchiolitis After Lung Transplantation
06:15

Author Spotlight: Investigating the Key Factors of Obliterative Bronchiolitis After Lung Transplantation

Published on: November 10, 2023

927

Related Experiment Videos

Last Updated: Jul 19, 2025

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation
10:01

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation

Published on: July 10, 2012

20.5K
Donor Posterior Atrial Flap Rotation for Left Atrial Cuff Reconstruction in Lung Transplantation
07:28

Donor Posterior Atrial Flap Rotation for Left Atrial Cuff Reconstruction in Lung Transplantation

Published on: October 11, 2024

387
Author Spotlight: Investigating the Key Factors of Obliterative Bronchiolitis After Lung Transplantation
06:15

Author Spotlight: Investigating the Key Factors of Obliterative Bronchiolitis After Lung Transplantation

Published on: November 10, 2023

927

Area of Science:

  • Critical Care Medicine
  • Pulmonology
  • Transplant Surgery

Background:

  • Diaphragm dysfunction impacts ventilator weaning outcomes in general ICU populations.
  • Limited data exists on diaphragm function and weaning in bilateral-lung transplant (BLT) recipients.
  • Previous studies used diaphragm thickening fraction (DTF) and neuroventilatory efficiency (NVE).

Purpose of the Study:

  • To investigate the incidence of diaphragm dysfunction in BLT recipients.
  • To determine if DTF and NVE predict weaning outcomes in BLT patients.
  • To explore the association between mechanical ventilation duration and diaphragm dysfunction.

Main Methods:

  • Adult BLT patients undergoing their first spontaneous breathing trial (SBT) were assessed.
  • Diaphragm thickening fraction (ultrasound measure) and neuroventilatory efficiency were recorded.
  • Weaning outcomes were categorized as simple, difficult, or prolonged based on SBT success.

Main Results:

  • Diaphragm dysfunction occurred in 32% of subjects, exclusively in those with difficult weaning.
  • Lower DTF and NVE values were observed in patients with difficult weaning (P < 0.001).
  • Both DTF and NVE demonstrated high accuracy in predicting difficult weaning and inversely correlated with ventilation duration.

Conclusions:

  • Diaphragm dysfunction is prevalent post-BLT and associated with challenging weaning.
  • Reduced DTF and NVE levels are characteristic of difficult weaning in this population.
  • DTF and NVE are reliable predictors of weaning success, with longer ventilation inversely affecting these measures.