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Related Experiment Videos

Identification of a putative second T-cell receptor.

M B Brenner, J McLean, D P Dialynas

    Nature
    |July 10, 1986
    PubMed
    Summary

    Researchers discovered a new human lymphocyte subset expressing T3 glycoprotein but lacking T-cell receptor (TCR) alpha/beta chains. These cells possess unique T3-associated polypeptides, including potential T gamma and T delta subunits, expanding our understanding of lymphocyte subsets.

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    Area of Science:

    • Immunology
    • Cell Biology
    • Molecular Genetics

    Background:

    • Human lymphocytes typically express T-cell receptors (TCRs) composed of alpha and beta subunits.
    • The T3 glycoprotein complex is a crucial component associated with the TCR on the cell surface.

    Purpose of the Study:

    • To characterize a distinct population of human lymphocytes identified by specific monoclonal antibodies.
    • To investigate the molecular composition of the T3 glycoprotein complex in these novel lymphocytes.

    Main Methods:

    • Utilized framework monoclonal antibodies for lymphocyte identification and characterization.
    • Performed chemical crosslinking experiments to analyze cell surface protein complexes.

    Main Results:

    Related Experiment Videos

  • Identified human lymphocytes expressing T3 glycoprotein but lacking canonical TCR alpha and beta subunits.
  • Discovered novel T3-associated polypeptides in these lymphocytes.
  • One associated polypeptide corresponds to the T gamma gene product, and another may represent a fourth TCR subunit, T delta.

    • Conclusions:

    • These findings reveal a previously unrecognized subset of human lymphocytes.
    • The novel T3-associated polypeptides suggest a distinct T-cell receptor or related complex.
    • This discovery has implications for understanding T-cell differentiation and function.