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Challenges and Opportunities for Celecoxib Repurposing.

Urszula Bąk1, Anna Krupa2

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Drug repositioning accelerates new drug development. This review explores new therapeutic targets for celecoxib, a selective COX-2 inhibitor, discussing its potential in cancer, mental disorders, and infectious diseases.

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Area of Science:

  • Pharmacology
  • Drug Discovery
  • Medicinal Chemistry

Background:

  • Drug repositioning is a key strategy for accelerating novel drug development.
  • Repurposing existing drugs with known safety profiles offers a promising avenue for discovering new therapeutic applications.
  • Celecoxib, a selective COX-2 inhibitor, has shown potential beyond its initial anti-inflammatory indications.

Purpose of the Study:

  • To review recent efforts in identifying novel therapeutic targets for celecoxib.
  • To explore the expanded clinical potential of celecoxib in areas such as oncology, psychiatry, and infectious diseases.
  • To discuss formulation challenges and advancements for developing new drug delivery systems for celecoxib.

Main Methods:

  • Comprehensive literature search of MEDLINE PubMed, Scopus, and clinical trial registries.
  • Analysis of existing data on celecoxib's efficacy and safety in various therapeutic contexts.
  • Review of pharmaceutical technologies for optimizing celecoxib's formulation and delivery.

Main Results:

  • Identification of emerging therapeutic applications for celecoxib beyond its anti-inflammatory role.
  • Discussion of celecoxib's potential in metronomic cancer therapy, mental disorders, and infectious diseases.
  • Overview of formulation strategies including nanocarriers, microparticles, and lipid-based systems to address physicochemical challenges.

Conclusions:

  • Celecoxib exhibits significant potential for repositioning into new therapeutic areas.
  • Overcoming formulation and delivery challenges is crucial for realizing celecoxib's expanded clinical utility.
  • Drug repositioning of celecoxib represents a valuable strategy for drug discovery and development.