Advances in Structure Pharmaceutics from Discovery to Evaluation and Design

Area of Science:

• Pharmaceutics
• Materials Science
• Biomedical Engineering

Background:

• Drug delivery systems (DDSs) are crucial for targeted active pharmaceutical ingredient (API) delivery.
• While API and excipient properties are well-studied, DDS structural characteristics remain underexplored.
• Structure pharmaceutics investigates DDS 3D structures and their physiological interactions.

Purpose of the Study:

• To provide a systematic overview of DDS structures and their influence on drug release and targeting.
• To discuss structure-based strategies for DDS design and evaluation.
• To explore structure-property relationships in various dosage forms.

Main Methods:

• Systematic review of diverse DDS structures (tablets, nanoparticles, etc.).
• Analysis of structure-release kinetics correlations (in vitro and in vivo).
• Evaluation of structure-based organ and tumor targeting capabilities.

Main Results:

• DDS structure significantly influences release kinetics and targeting efficiency.
• Different particle structures exhibit varying organ- and tumor-targeting abilities.
• Structural strategies can be applied to DDS design and performance evaluation.

Conclusions:

• Structure pharmaceutics is vital for advancing DDS design and optimizing therapeutic outcomes.
• Further research into DDS structural characteristics will enhance drug delivery efficacy.
• Characterization techniques in structure pharmaceutics offer future application potential.