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Serum MicroRNA-191-5p Levels in Vascular Complications of Type 1 Diabetes: The EURODIAB Prospective Complications

Stefania Bellini1, Simonetta Guarrera2,3, Giuseppe Matullo1,4

  • 1Department of Medical Sciences, University of Turin, 10126 Turin, Italy.

The Journal of Clinical Endocrinology and Metabolism
|August 8, 2023
PubMed
Abstract

Insights

Serum levels of microRNA-191-5p were significantly lower in type 1 diabetes patients with chronic vascular complications. Lower microRNA-191-5p levels are independently associated with an increased risk of diabetic complications, including cardiovascular disease and albuminuria.

Area of Science:

  • Biochemistry
  • Genetics
  • Endocrinology

Background:

  • MicroRNA-191-5p plays a role in cellular processes relevant to diabetic complications like angiogenesis and inflammation.
  • Circulating microRNA-191-5p levels in chronic diabetes complications have not been previously studied.

Purpose of the Study:

  • To investigate the association between serum microRNA-191-5p levels and micro- and macrovascular disease in type 1 diabetes mellitus (DM1).

Main Methods:

  • Quantitative PCR was used to measure microRNA-191-5p levels in 420 DM1 patients from the EURODIAB Prospective Complication Study.
  • Logistic regression analysis was employed to assess the independent association of microRNA-191-5p with diabetes complications, comparing cases (with complications) and controls (without complications).

Main Results:

  • MicroRNA-191-5p levels were significantly reduced in DM1 patients with chronic complications compared to controls.
  • Reduced microRNA-191-5p was independently associated with a lower odds of developing chronic diabetes complications, including cardiovascular disease, albuminuria, and retinopathy.

Conclusions:

  • Serum microRNA-191-5p is inversely associated with vascular chronic complications in type 1 diabetes mellitus.
  • Lower levels of microRNA-191-5p may serve as a potential biomarker for predicting the risk of vascular complications in DM1.
Keywords:
albuminuriacardiovascular diseasesdiabetic complicationsdiabetic nephropathymicroRNAstype 1 diabetes

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