Serum osmolality measured in fingertip capillary blood is comparable to serum osmolality measured in venous blood
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Updated: Jul 19, 2025

Non-invasive Assessment of Microvascular and Endothelial Function
Published on: January 29, 2013
K Bergin-Taylor1, M P Funnell1, R A Ferguson1
1National Centre for Sport and Exercise Medicine, School of Sport Exercise and Health Sciences, Loughborough University, Loughboroug LE11 3TU, UK.
Abstract:
Blood osmolality is considered the gold standard hydration assessment, but has limited application for technical and invasive reasons. Paired antecubital-venous blood and fingertip-capillary blood were collected pre- and 30 min post-drinking 600 mL water in 55 male/female participants. No bias (0.2 mOsmo/kg, limits of agreement = -2.5 to 2.8 mOsmo/kg) was found between sampling methods, with high linear correlation (Spearman's r = 0.95, P < 0.001). Capillary blood sampling offers an accurate less-invasive method for determining serum osmolality than venous blood sampling.
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