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Evolutionary Relationships through Genome Comparisons02:54

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Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
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Inferring the Direction of Introgression Using Genomic Sequence Data.

Yuttapong Thawornwattana1, Jun Huang2, Tomáš Flouri3

  • 1Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.

Molecular Biology and Evolution
|August 8, 2023
PubMed
Summary
This summary is machine-generated.

Inferring the direction of gene flow using genomic data is challenging. New methods show it’s easier to detect gene flow from smaller to larger populations and from outgroups to ingroups.

Keywords:
Bppdirection of gene flowgene flowintrogressionmultispecies coalescent

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Area of Science:

  • Evolutionary Biology
  • Genomics
  • Population Genetics

Background:

  • Genomic data reveal species divergence and gene flow history.
  • Inferring the direction of gene flow is difficult due to similar patterns from bidirectional gene flow.

Purpose of the Study:

  • Investigate the information in genomic sequence data for inferring gene flow direction.
  • Develop and apply likelihood-based methods under the multispecies-coalescent-with-introgression model.

Main Methods:

  • Utilized likelihood-based methods and the multispecies-coalescent-with-introgression model.
  • Analyzed genomic sequences from two species, with simulations for three or four species.
  • Applied methods to genomic data from Heliconius butterflies.

Main Results:

  • Inferred gene flow is easier from small to large populations and from outgroups to ingroups.
  • Gene flow detection is more successful with longer separate evolution times.
  • Incorrectly inferred introgression direction can lead to accurate timing estimates and significant Bayesian tests.

Conclusions:

  • Genomic datasets are informative for determining the direction, timing, and strength of interspecific gene flow.
  • The developed methods enhance our ability to reconstruct complex evolutionary histories.