Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Intrathecal morphine for post-thoracotomy pain.

J R Gray, G A Fromme, L A Nauss

    Anesthesia and Analgesia
    |August 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Optimal testing parameters for blood cultures.

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2004
    Same author

    Detection of herpes simplex virus DNA in genital and dermal specimens by LightCycler PCR after extraction using the IsoQuick, MagNA Pure, and BioRobot 9604 methods.

    Journal of clinical microbiology·2001
    Same author

    Laparoscopic ultrasonography: a training model.

    Diseases of the colon and rectum·2001
    Same author

    A prospective randomized comparison of laparoscopic appendectomy with open appendectomy: Clinical and economic analyses.

    Surgery·2001
    Same author

    Characteristics and evolution of extraintestinal manifestations associated with ulcerative colitis after proctocolectomy.

    Digestive surgery·2001
    Same author

    Surgical repair of chronic rotator cuff tears. A prospective long-term study.

    The Journal of bone and joint surgery. American volume·2001

    Intrathecal morphine in normal saline provided longer pain relief than hyperbaric solutions after thoracic surgery. This formulation may enhance postoperative analgesia duration while maintaining a similar safety profile regarding respiratory depression.

    Area of Science:

    • Anesthesiology
    • Pharmacology

    Background:

    • Post-thoracotomy pain management often involves intrathecal analgesics.
    • Optimizing the formulation of intrathecal morphine is crucial for balancing efficacy and safety.

    Purpose of the Study:

    • To compare the duration of postoperative analgesia and incidence of respiratory depression between hypobaric (normal saline) and hyperbaric (dextrose) intrathecal morphine solutions.
    • To evaluate the optimal formulation of intrathecal morphine for post-thoracotomy pain relief.

    Main Methods:

    • A comparative study involving 50 patients undergoing thoracic surgery.
    • Intrathecal injection of 10 µg/kg morphine in either preservative-free normal saline (hypobaric) or dextrose (hyperbaric).
    • Assessment of postoperative analgesia duration and monitoring for respiratory depression.

    Related Experiment Videos

    Main Results:

    • Analgesia duration was significantly longer in the normal saline group compared to the hyperbaric dextrose group (P < 0.04).
    • One patient experienced delayed respiratory depression, with no significant difference noted between groups.
    • Intrathecal morphine in normal saline demonstrated superior analgesic efficacy.

    Conclusions:

    • Morphine in normal saline offers a greater duration of analgesia for post-thoracotomy pain compared to hyperbaric solutions.
    • The use of morphine in normal saline is supported for enhanced postoperative pain management after thoracic operations.
    • Formulation choice impacts analgesic duration without significantly altering respiratory safety profiles.