Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Role of Cerebellum and Prefrontal Cortex in Memory

Role of Cerebellum and Prefrontal Cortex in Memory

The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...

Cognitive Development During Adulthood

Cognitive Development During Adulthood

Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Visuomotor flexibility is embedded in the topography of frontal cortex.

bioRxiv : the preprint server for biology·2026

Same author

A Scalable Touchscreen-Based Spatial Working Memory Task for Cross-Species Research.

bioRxiv : the preprint server for biology·2026

Same author

Attentional Deficits Do Not Explain Age-Related Impairments on the Mnemonic Similarity Task.

Hippocampus·2026

Same author

Digital memory assessments and plasma pTau217 enable efficient preclinical Alzheimer's trials.

The journal of prevention of Alzheimer's disease·2026

Same author

Uniform Amyloid Thresholds Across Populations.

JAMA neurology·2026

Same author

Cognitive Strategy Accounts for Failure on a Relational Memory Task in Non-Human Primates.

Hippocampus·2026

Search research articles

Related Experiment Video

Updated: Jul 19, 2025

Chronic Implantation of Whole-cortical Electrocorticographic Array in the Common Marmoset

Chronic Implantation of Whole-cortical Electrocorticographic Array in the Common Marmoset

Published on: February 1, 2019

Domain-Specific Cognitive Impairment Reflects Prefrontal Dysfunction in Aged Common Marmosets.

Casey R Vanderlip¹, Payton A Asch¹, John H Reynolds¹

¹Systems Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037.

|August 8, 2023

Summary

Aged marmosets show impaired cognitive flexibility, particularly in tasks involving the prefrontal cortex. This suggests marmosets are a valuable model for studying cognitive aging and its neural basis.

Keywords:

aging cognition cognitive impairment marmoset prefrontal proactive interference

More Related Videos

The Attentional Set Shifting Task: A Measure of Cognitive Flexibility in Mice

The Attentional Set Shifting Task: A Measure of Cognitive Flexibility in Mice

Published on: February 4, 2015

The Double-H Maze: A Robust Behavioral Test for Learning and Memory in Rodents

The Double-H Maze: A Robust Behavioral Test for Learning and Memory in Rodents

Published on: July 8, 2015

Related Experiment Videos

Last Updated: Jul 19, 2025

Chronic Implantation of Whole-cortical Electrocorticographic Array in the Common Marmoset

Chronic Implantation of Whole-cortical Electrocorticographic Array in the Common Marmoset

Published on: February 1, 2019

The Attentional Set Shifting Task: A Measure of Cognitive Flexibility in Mice

The Attentional Set Shifting Task: A Measure of Cognitive Flexibility in Mice

Published on: February 4, 2015

The Double-H Maze: A Robust Behavioral Test for Learning and Memory in Rodents

The Double-H Maze: A Robust Behavioral Test for Learning and Memory in Rodents

Published on: July 8, 2015

Area of Science:

Neuroscience
Cognitive Aging Research
Primate Models

Background:

Age-related cognitive decline varies across cognitive domains.
The common marmoset is a growing model in neuroscience but lacks comprehensive cognitive aging studies.
Understanding marmoset cognitive aging is crucial for evaluating them as a model for human aging.

Purpose of the Study:

To characterize age-related cognitive changes in marmosets across multiple domains.
To investigate stimulus-reward association learning and cognitive flexibility in aging marmosets.
To determine if marmosets exhibit domain-specific cognitive impairments analogous to humans.

Main Methods:

Utilized Simple Discrimination task for stimulus-reward association learning.
Employed Serial Reversal task to assess cognitive flexibility.
Compared cognitive performance between young adult and geriatric marmosets.

Main Results:

Aged marmosets demonstrated transient impairments in learning-to-learn abilities.
The capacity to form stimulus-reward associations remained largely conserved in older marmosets.
Older marmosets exhibited reduced cognitive flexibility, linked to heightened susceptibility to proactive interference.

Conclusions:

Cognitive aging in marmosets impacts prefrontal cortex-dependent functions, specifically cognitive flexibility.
Findings support the hypothesis that prefrontal cortical dysfunction is a key aspect of neurocognitive aging.
The marmoset serves as a significant model for elucidating the neural mechanisms underlying cognitive aging.