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Related Experiment Videos

Acute intoxication due to ibuprofen overdose.

C Y Lee, A Finkler

    Archives of Pathology & Laboratory Medicine
    |August 1, 1986
    PubMed
    Summary
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    A severe ibuprofen overdose led to multiple organ failure, including acute kidney and liver injury. Despite critical complications, the patient achieved full recovery, highlighting the potential for resolution even in severe cases.

    Area of Science:

    • Pharmacology
    • Toxicology
    • Internal Medicine

    Background:

    • Ibuprofen is a common nonsteroidal anti-inflammatory drug (NSAID) used for pain and inflammation.
    • Overdosing on ibuprofen can lead to serious toxic effects and organ damage.

    Observation:

    • A male patient ingested a massive dose of ibuprofen (>20 g).
    • Serum ibuprofen levels were significantly elevated, with detectable metabolites (2-carboxyibuprofen, 2-hydroxyibuprofen) at 10 and 67 hours post-ingestion.

    Findings:

    • The patient developed severe metabolic acidosis, acute renal failure, acute liver-cell injury, acute cholestasis, and thrombocytopenia.
    • Complications included respiratory failure, hypotension, and upper gastrointestinal tract bleeding.

    Implications:

    Related Experiment Videos

    • This case demonstrates the potential for severe multi-organ dysfunction following a massive ibuprofen overdose.
    • Despite the critical presentation, complete resolution of organ failure is possible with intensive medical management.
    • Highlights the importance of monitoring and supportive care in managing NSAID toxicity.