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Relationship between testosterone and male bladder cancer.

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This study found a significant correlation between higher serum total testosterone levels and bladder cancer (BC) occurrence in men. Other factors like hemoglobin, hypertension, diabetes, and smoking also showed associations with BC risk.

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Area of Science:

  • Urology
  • Oncology
  • Endocrinology

Background:

  • Bladder cancer (BC) incidence is notably higher in men than women.
  • This disparity suggests a potential role for androgens, such as testosterone, in BC development.

Purpose of the Study:

  • To investigate the association between androgen levels and bladder cancer.
  • To identify potential risk factors contributing to bladder cancer in a male-predominant population.

Main Methods:

  • A case-control study included 147 primary bladder cancer patients and 154 controls.
  • Statistical analyses included Mann-Whitney U tests, Chi-square tests, and univariate/multivariate logistic regression.
  • Serum total testosterone levels and other clinical factors were analyzed for correlation with BC.

Main Results:

  • Multivariate analysis revealed a significant correlation between serum total testosterone levels and bladder cancer (OR 1.002, P=0.017).
  • Hemoglobin levels (OR 0.981, P=0.002), hypertension (OR 2.780, P<0.001), diabetes (OR 3.313, P=0.008), and smoking (OR 1.938, P=0.009) were also significantly associated with BC.
  • Univariate analysis showed similar significant differences for these factors.

Conclusions:

  • Serum total testosterone levels are significantly correlated with the occurrence of bladder cancer.
  • Factors including hemoglobin, hypertension, diabetes, and smoking are also independently associated with bladder cancer risk.