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The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

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Related Experiment Video

Updated: Jul 19, 2025

Three-dimensional Cell Culture Model for Measuring the Effects of Interstitial Fluid Flow on Tumor Cell Invasion

Three-dimensional Cell Culture Model for Measuring the Effects of Interstitial Fluid Flow on Tumor Cell Invasion

Published on: July 25, 2012

Changes in Tissue Fluidity Predict Tumor Aggressiveness In Vivo.

Frank Sauer¹, Steffen Grosser^1,2, Mehrgan Shahryari³

¹Soft Matter Physics Division, Peter-Debye-Institute for Soft Matter Physics, 04103, Leipzig, Germany.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)

|August 9, 2023

Summary

Cancer progression involves tissue fluidization, not just stiffness. New physics-based models and magnetic resonance elastography (MRE) reveal mechanical properties predicting tumor aggressiveness and metastasis.

Keywords:

cancer in vivo magnetic resonance elastography medical imaging tissue fluidity tumor mechanics

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Last Updated: Jul 19, 2025

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Area of Science:

Biophysics
Cancer Biology
Medical Imaging

Background:

Tumor mechanical properties, particularly stiffness, are linked to cancer progression but offer limited prognostic value.
Cancer progression is hypothesized to involve tissue fluidization, enabling cell movement and metastasis.
Understanding the mechanical alterations in tumors is crucial for predicting cancer behavior.

Conclusions:

Tissue fluidization is a key aspect of cancer progression, alongside stiffness changes.
Mechanical properties like stiffness, fluidity, heterogeneity, and texture at the tumor front can serve as a roadmap for prognosis.
A physics-based approach integrating mechanical markers offers a new strategy for predicting tumor aggressiveness and metastatic potential.