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Updated: Jul 19, 2025

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
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Vitamin D Receptor Expression in Chronic Plaque Psoriasis Before and After Narrowband Ultraviolet B Phototherapy

Lamia H Elgarhy1, Rania A Eltatawy1, Omnia Rizk2

  • 1Department of Dermatology and Venereology, Faculty of Medicine, Tanta University, Tanta, Egypt.

Journal of Cutaneous and Aesthetic Surgery
|August 9, 2023
PubMed
Abstract

Insights

Psoriasis involves genetic, immune, and environmental factors. Narrow-band UVB therapy increased Vitamin D receptor (VDR) expression in psoriatic skin lesions, suggesting a therapeutic benefit for this condition.

Area of Science:

  • Dermatology
  • Molecular Biology
  • Phototherapy

Background:

  • Psoriasis is a complex, multifactorial skin disease influenced by genetic, immunological, and environmental factors.
  • The Vitamin D receptor (VDR) plays a crucial role in regulating epidermal cell growth, including keratinocyte proliferation and differentiation.

Purpose of the Study:

  • To investigate the impact of Narrow-band UVB (NB-UVB) therapy on Vitamin D receptor (VDR) expression in the skin of patients with psoriasis.

Main Methods:

  • Forty patients with varying psoriasis severities were included.
  • Skin biopsies (lesional and non-lesional) were collected before and after 24 NB-UVB sessions.
  • Immunohistochemistry was used to assess VDR expression levels.

Main Results:

  • VDR expression was significantly lower in psoriatic lesions compared to non-lesional skin prior to treatment.
  • Lower VDR expression correlated negatively with Psoriasis Area and Severity Index (PASI) score, family history, and disease duration.
  • NB-UVB therapy led to a significant increase in VDR expression in lesional skin post-treatment.

Conclusions:

  • Vitamin D receptor (VDR) expression is downregulated in psoriatic skin lesions.
  • NB-UVB therapy demonstrates a positive effect by improving VDR expression in psoriasis skin lesions.
Keywords:
NB-UVBpsoriasisvitamin D receptor

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