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Pathophysiological consequences and treatment strategy of obstructive jaundice
Jun-Jian Liu1, Yi-Meng Sun2, Yan Xu2
1Department of Hepatobiliary and Pancreatic Surgery, Tianjin Medical University Nankai Hospital, Tianjin 300102, China.
World Journal of Gastrointestinal Surgery
|August 9, 2023
Summary
Obstructive jaundice (OJ) involves widespread pathophysiological changes affecting liver function and leading to systemic complications. Management strategies include supportive care, medical interventions, and surgical or endoscopic procedures.
Area of Science:
- Hepatology
- Gastroenterology
- Internal Medicine
Background:
- Obstructive jaundice (OJ) presents significant clinical challenges due to complex pathophysiological alterations.
- Understanding OJ's systemic effects, including endotoxemia and multiple organ dysfunction syndrome, is crucial for effective patient care.
Purpose of the Study:
- To comprehensively review the pathophysiological changes associated with obstructive jaundice.
- To outline current and potential management strategies for obstructive jaundice.
Main Methods:
- A comprehensive literature search was performed on PubMed.
- Articles published up to August 1970 were included in the review.
Main Results:
- Obstructive jaundice impacts the biliary tree, hepatic cells, and overall liver function.
- Systemic complications arise from intestinal endotoxin absorption, leading to inflammatory responses and potential organ dysfunction.
Conclusions:
- Effective management of obstructive jaundice requires addressing fluid and electrolyte balance, nutrition, infection, and symptoms like pain and itching.
- Treatment options encompass biliary drainage, surgical interventions, endoscopic procedures, and consideration of Traditional Chinese Medicine.
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