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Interaction between atracurium and suxamethonium in the dog
Research in Veterinary Science
|May 1, 1986
Summary
Prior administration of atracurium shortened suxamethonium
Area of Science:
- Veterinary Anesthesia
- Neuromuscular Pharmacology
Background:
- Suxamethonium is a depolarizing neuromuscular blocking agent.
- Atracurium is a non-depolarizing neuromuscular blocking agent.
Purpose of the Study:
- To investigate the interaction between suxamethonium and atracurium in dogs.
- To determine the effect of sequential administration on neuromuscular blockade duration.
Main Methods:
- Four dogs received suxamethonium (0.3 mg kg-1) and atracurium (0.6 mg kg-1) in separate experimental series.
- Drugs were administered sequentially, with the second drug given at 50% recovery of neuromuscular activity.
- Atropine and neostigmine were used to reverse the block.
Main Results:
- Prior atracurium administration reduced the duration of suxamethonium's action.
- Prior suxamethonium administration did not significantly affect atracurium's duration of action.
Conclusions:
- Atracurium can potentiate the neuromuscular blocking effects of suxamethonium.
- The sequence of administration is critical when combining these neuromuscular blocking agents.