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Development of Amelogenin-chitosan Hydrogel for In Vitro Enamel Regrowth with a Dense Interface

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Developing Bioactive Dental Resins for Restorative Dentistry.

M A S Melo^1,2, I M Garcia¹, L Mokeem²

¹Division of Operative Dentistry, Department of General Dentistry, University of Maryland School of Dentistry, Baltimore, MD, USA.

Journal of Dental Research

|August 9, 2023

Summary

This summary is machine-generated.

Developing new bioactive dental resins aims to prevent secondary caries, the main cause of restoration failure. Researchers are exploring agents to enhance antimicrobial and remineralization properties while overcoming formulation challenges for better clinical performance.

Keywords:

composite dental resin dental caries dentin-bonding agents nanotechnology tooth remineralization

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Area of Science:

Dental Materials Science
Biomaterials Engineering
Caries Research

Background:

Resin-based dental materials are widely used but prone to secondary caries, primarily due to acidogenic bacteria in high-risk patients.
Secondary caries and material biodegradation significantly reduce the lifespan of dental restorations.
There is a growing need for advanced restorative materials with antimicrobial properties to combat secondary caries.

Purpose of the Study:

To review the development of novel bioactive resins for enhanced secondary caries prevention.
To explore strategies for incorporating anticaries agents into dental materials.
To synthesize current advancements, challenges, and clinical translation of bioactive dental resins.

Main Methods:

Systematic review of literature on bioactive resin development.
Analysis of formulation strategies for antimicrobial and remineralization functionalities.
Evaluation of clinical performance prerequisites and material vulnerabilities.

Main Results:

Secondary caries remains the leading cause of resin-based restoration failure.
Development focuses on bioactive resins with enhanced antibiofilm and remineralization capabilities.
Challenges include agent safety, material property preservation, and clinical translation.

Conclusions:

Novel bioactive resins offer promising solutions for secondary caries prevention.
Overcoming formulation challenges like particle aggregation and hydrolysis is crucial for clinical success.
Further research is needed to ensure long-term performance and favorable clinical outcomes of these advanced dental materials.