Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Osmotic mini-pumps: a convenient program for weight-adjusted filling concentrations.

A J Greenshaw

    Brain Research Bulletin
    |May 1, 1986
    PubMed
    Summary

    This study presents a BASIC computer program to accurately calculate drug concentrations for ALZET osmotic mini-pumps. The program simplifies solution preparation for chronic drug and hormone administration studies, ensuring reliable results.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Methodological approaches to situational analysis in global mental health: a scoping review.

    Global mental health (Cambridge, England)·2019
    Same author

    Aversive stimulus properties of the 5-HT2C receptor agonist WAY 161503 in rats.

    Neuropharmacology·2006
    Same author

    Facilitation of brain stimulation reward by MK-801 (dizocilpine) may be independent of D2-like dopamine receptor stimulation in rats.

    Psychopharmacology·2005
    Same author

    Differential effects of intra-midbrain raphe and systemic 8-OH-DPAT on VTA self-stimulation thresholds in rats.

    Psychopharmacology·2004
    Same author

    The enigma of conditioned taste aversion learning: stimulus properties of 2-phenylethylamine derivatives.

    Physiological research·2002
    Same author

    Common effects of chronically administered antipanic drugs on brainstem GABA(A) receptor subunit gene expression.

    Molecular psychiatry·2001

    Area of Science:

    • Pharmacology
    • Biomedical Engineering
    • Computer Science

    Background:

    • Chronic drug and hormone administration is crucial in various research fields.
    • Accurate preparation of solutions for osmotic mini-pumps is essential for experimental validity.
    • Manual calculation of mini-pump filling concentrations can be time-consuming and prone to error.

    Purpose of the Study:

    • To describe a BASIC computer program designed to calculate filling concentrations for ALZET osmotic mini-pumps.
    • To provide researchers with a tool for rapid and accurate preparation of drug and hormone solutions for mini-pump studies.

    Main Methods:

    • Development of a user-friendly BASIC computer program.
    • Input parameters include daily dose, pump specifications, and animal weights.

    Related Experiment Videos

  • Program calculates total drug quantity, standard solution volume and concentration, and individual pump volumes.

    • Main Results:

    • The program provides the total quantity of drug/hormone needed for an experiment.
    • It determines the minimum standard solution volume and concentration with a 10% error margin.
    • Individual pump volumes are calculated to achieve desired concentrations upon dilution.

    Conclusions:

    • The developed program ensures reliably accurate and rapid preparation of solutions for mini-pump use.
    • It streamlines the process of chronic drug and hormone administration studies.
    • This tool enhances experimental reproducibility and efficiency in biomedical research.