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PREVALENCE OF SERRATED POLYPS AND THEIR ASSOCIATION WITH SYNCHRONOUS COLORECTAL ADVANCED ADENOMAS
Gilmara Coelho Meine1,2, Guilherme Becker Sander1
1Universidade Federal do Rio Grande do Sul, Escola de Medicina, Programa de Pós-graduação: Ciências em Gastroenterologia e Hepatologia, Porto Alegre, RS, Brasil.
Arquivos De Gastroenterologia
|August 9, 2023
Summary
Clinically significant serrated polyps (CSSP) and advanced adenomas appear with similar prevalence. CSSP increases the risk of advanced adenomas, particularly those located proximally.
Area of Science:
- Gastroenterology
- Oncology
- Endoscopy
Background:
- Serrated lesions precede up to one-third of colorectal cancers (CRC) and share features with interval CRC.
- Previous research shows varied serrated polyp prevalence and inconsistent associations with advanced adenomas.
Purpose of the Study:
- To determine the prevalence of serrated polyps.
- To evaluate the association between serrated polyps and synchronous advanced adenomas.
Main Methods:
- Retrospective analysis of 1208 colonoscopies in patients aged 45-75.
- Data collected on prevalence of serrated polyp subtypes and advanced adenomas.
- Multivariate analysis performed to assess associations.
Main Results:
- Prevalence: Clinically significant serrated polyps (CSSP) 11.3%, large serrated polyps (LSP) 6%, sessile serrated adenomas (SSA) 3.7%.
- CSSP associated with synchronous advanced adenomas (OR 2.121), especially proximal (OR 2.966).
- LSP (OR 2.872) and SSA (OR 5.032) linked to proximal advanced adenomas.
Conclusions:
- Prevalence of CSSP and advanced adenomas are comparable.
- CSSP is a risk factor for advanced adenomas, with a stronger link to proximal ones.
- LSP and SSA are specifically associated with proximal advanced adenomas.
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