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A computerized multichannel platelet aggregometer system.

D Kuzara, B J Zoltan, S L Greathouse

Journal of Pharmacological Methods

|August 1, 1986

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A new computerized multichannel aggregometer system (CMPAS) offers efficient, simultaneous platelet aggregation analysis for up to 24 samples. This advanced system improves drug screening and diagnosis of platelet disorders.

Area of Science:

Hematology
Biomedical Engineering
Pharmacology

Background:

Traditional aggregometers (1-4 channels) have limitations for large-scale drug screening and diagnosing platelet disorders.
Existing methods using strip chart recorders are inefficient for high-throughput analysis.

Purpose of the Study:

To develop and evaluate a novel computerized multichannel aggregometer system (CMPAS) for enhanced platelet aggregation studies.
To overcome the limitations of conventional aggregometers in research and clinical settings.

Main Methods:

A 24-channel Born-type aggregometer was interfaced with a microcomputer, analogue-to-digital converter, and printer.
Custom BASIC programs were developed for data collection, user prompts, and simultaneous display of aggregation tracings.

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Automated data analysis generated key aggregation parameters including optical density, response time, and slopes.

Main Results:

The CMPAS successfully collected and analyzed platelet aggregation data from up to 24 samples simultaneously.
Simultaneous display of all channels facilitated direct comparison between control and experimental groups.
Automated analysis provided quantitative parameters comparable to standard aggregometer units.

Conclusions:

The CMPAS provides a significant advancement for platelet aggregation studies, offering multichannel capability and automated analysis.
This system enhances efficiency and accuracy in drug screening, mode of action studies, and clinical diagnosis of platelet function.
The CMPAS represents a valuable tool for researchers and clinicians investigating platelet aggregation dynamics.