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Hailey-Hailey disease successfully treated with photodynamic therapy: Case report
Natalia Teplyuk1, Anfisa Lepekhova1, Ekaterina Dunaeva1
1Department of Dermatology and Venereology, I.M. Sechenov First Moscow State Medical University (Sechenov University), Trubetskaya str, 8, Moscow, Russian Federation.
Photodiagnosis and Photodynamic Therapy
|August 9, 2023
Summary
Hailey-Hailey disease (HHD), a rare genetic blistering condition, can be effectively managed. Photodynamic therapy (PDT) with a liposomal chlorin photosensitizer offers a promising treatment option for HHD.
Area of Science:
- Dermatology
- Genetics
- Photomedicine
Background:
- Hailey-Hailey disease (HHD) is a rare, autosomal dominant genetic disorder characterized by blistering, primarily affecting skin folds.
- Mutations in the ATP2C1 gene are the primary cause of HHD, leading to variable expressivity.
- Triggers include sweating, infection, trauma, and UV radiation, complicating management.
Observation:
- HHD lesions present as flaccid vesicles and blisters on erythematous skin in intertriginous areas.
- Erosions, fissures, and vegetations are common sequelae of the blistering.
- Current therapeutic approaches focus on managing triggers, secondary infections, and inflammation, with limited evidence for specific treatments.
Findings:
- A case of Hailey-Hailey disease was successfully treated using photodynamic therapy (PDT).
- The treatment involved a topical liposomal chlorin photosensitizer.
- This suggests PDT as a viable therapeutic option for recalcitrant HHD.
Implications:
- Photodynamic therapy (PDT) presents a novel and effective treatment strategy for Hailey-Hailey disease.
- This case highlights the potential of PDT in managing rare genetic skin conditions.
- Further research into PDT for HHD could lead to improved patient outcomes and quality of life.
