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Occlusion of the Great and Small Saphenous Vein Using Copolymeric Glue Based on N-Butyl Cyanoacrylate and Methacryloxy Sulfolane
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Occlusion of the Great and Small Saphenous Vein Using Copolymeric Glue Based on N-Butyl Cyanoacrylate and Methacryloxy Sulfolane

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[Sclerotherapy of varices and protein C deficiency]

C Lecerf, B Hutinel, S Combe-Tamzali

    Phlebologie
    |April 1, 1986
    PubMed

    Insights

    A woman

    Area of Science:

    • Genetics
    • Hematology

    Background:

    • Hereditary thrombophilia
    • Protein C deficiency

    Observation:

    • Relapsing venous thrombosis after variceal sclerosis
    • Autosomal dominant inheritance pattern
    • Clinical heterogeneity in affected family members

    Findings:

    • Quantitative protein C deficiency identified
    • Family history reveals affected father and siblings
    • Heterogeneous clinical manifestations observed

    Implications:

    • Pregnancy poses risks for women with protein C deficiency
    • Anticoagulant therapy (heparin, vitamin K antagonists) for thromboembolism
    • Prophylactic anticoagulation recommended for asymptomatic individuals in high-risk situations

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