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Related Experiment Videos

Brainstem auditory pathway degeneration associated with chronic cochlear implants in the monkey.

J M Miller, D Sutton, L Carlisle

    American Journal of Otolaryngology
    |July 1, 1986
    PubMed
    Summary

    Cochlear implants can cause long-term degeneration in the central auditory pathway. This study in monkeys shows damage progresses over time, affecting multiple auditory system levels.

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    Musculoskeletal science & practice·2018

    Area of Science:

    • Neuroscience
    • Auditory System Research
    • Medical Device Impact Studies

    Background:

    • Cochlear implants are vital for hearing restoration.
    • Understanding the long-term effects of cochlear prostheses on the central auditory pathway is crucial.

    Purpose of the Study:

    • To investigate the pattern and extent of neural degeneration in the central auditory pathway after cochlear implant use.
    • To determine if factors associated with cochlear prostheses contribute to ongoing neural damage.

    Main Methods:

    • Histological examination of cochleas and brainstems in monkeys following cochlear implantation.
    • Varied implantation techniques and cochlear treatments (e.g., neomycin perfusion) were employed.
    • Animals were maintained for 5 to 120 weeks post-implantation.

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    Main Results:

    • Spiral ganglion cell loss varied, correlating with neural degeneration in the cochlear nucleus.
    • Peripheral damage extended towards the cochlear apex over time, mirrored by a shift in cochlear nucleus degeneration.
    • Transneuronal degeneration was observed in the superior olive, lateral lemniscus, and inferior colliculus.

    Conclusions:

    • Cochlear prosthesis use, including insertion trauma and electrical stimulation, may induce progressive central auditory pathway degeneration.
    • This degeneration is a long-term process affecting multiple auditory system levels.
    • Further research is needed to mitigate these adverse effects.