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Updated: Jul 19, 2025

Continuous Telemetric In Utero Tracheal Pressure Measurements in Fetal Lambs
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Continuous Telemetric In Utero Tracheal Pressure Measurements in Fetal Lambs

Published on: December 22, 2023

335

Developmental consequences of short apneas and periodic breathing in preterm infants

Alicia K Yee1, Leon S Siriwardhana1, Gillian M Nixson1,2

  • 1Department of Paediatrics, Monash University, Melbourne, VIC, Australia.

Journal of Perinatology : Official Journal of the California Perinatal Association
|August 9, 2023
PubMed

Insights

Respiratory events in preterm infants before hospital discharge impact later development. Increased time with respiratory events at term predicted lower language and motor scores at 6 months corrected age.

Area of Science:

  • Neonatal development
  • Respiratory physiology in infants

Background:

  • Preterm infants often experience respiratory events.
  • Understanding the long-term impact of these events is crucial for developmental outcomes.

Purpose of the Study:

  • To investigate the association between respiratory events and developmental outcomes in preterm infants.
  • To identify predictors of developmental outcomes at 6 months corrected age.

Main Methods:

  • Studied preterm infants (28-32 weeks gestational age) at multiple time points.
  • Calculated percentage total sleep time (%TST) with respiratory events (apneas, periodic breathing).
  • Used stepwise multiple linear regression to identify significant predictors.

Main Results:

  • %TST with respiratory events at term was a significant predictor of language and motor scores.
  • A higher %TST with respiratory events correlated with lower composite scores on the Bayley Scales of Infant Development.
  • These findings were independent of gestational age, birth weight, and sex.

Conclusions:

  • In stable very preterm infants, time spent with respiratory events at term equivalent age is linked to reduced language and motor outcomes at 6 months corrected age.
  • Early respiratory event management may be important for optimizing neurodevelopmental trajectories.
Abstract

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