Related Experiment Video

Updated: Jul 19, 2025

Author Spotlight: Developing a Bedside Protocol for Kidney and Genitourinary Ultrasonography
03:19

Author Spotlight: Developing a Bedside Protocol for Kidney and Genitourinary Ultrasonography

Published on: June 21, 2024

1.2K

Kidney Considerations in Pediatric Obesity

Alexandra Sawyer1, Evan Zeitler2, Howard Trachtman3

  • 1Department of Pediatrics, Division of Endocrinology, University of Colorado School of Medicine, 13123 East 16Th Avenue, Box 158, Aurora, CO, 80045, USA. Alexandra.sawyer@childrenscolorado.org.

Current Obesity Reports
|August 9, 2023
PubMed

Insights

Obesity-related kidney disease and diabetic kidney disease can affect children, potentially leading to chronic kidney disease later in life. Early detection of kidney injury in pediatric populations is crucial for intervention.

Area of Science:

  • Pediatric Nephrology
  • Endocrinology
  • Public Health

Background:

  • Chronic kidney disease (CKD) poses significant risks in adults, with children and adolescents also susceptible to early kidney injury.
  • Obesity is a key contributor to CKD development through direct and indirect pathways.
  • Understanding pediatric kidney disease is vital for long-term health outcomes.

Purpose of the Study:

  • To review obesity-related kidney disease (ORKD) and diabetic kidney disease (DKD) in the pediatric population.
  • To describe the impact of ORKD and DKD on children and adolescents.
  • To highlight the importance of early detection and intervention.

Main Methods:

  • Literature review of pediatric obesity and kidney disease.
  • Analysis of early kidney injury phenotypes.
  • Examination of emerging therapeutic strategies.

Main Results:

  • Obesity-related CKD is uncommon in pediatric populations but increases lifetime CKD risk.
  • Glomerular hyperfiltration is an early indicator for both ORKD and DKD, preceding albuminuria and GFR decline.
  • Novel treatments for pediatric obesity and type 2 diabetes with kidney-protective effects are under investigation.

Conclusions:

  • Early kidney damage in pediatric obesity and diabetes can have lasting consequences.
  • Identifying early signs like glomerular hyperfiltration is key for timely intervention.
  • Further research is needed to fully understand and manage kidney disease in pediatric populations.
Abstract

Keywords:
Diabetic kidney diseaseObesity-related glomerulopathyObesity-related kidney diseasePediatric obesity

More Related Videos

Robot-Assisted Kidney Transplantation07:30

Robot-Assisted Kidney Transplantation

Published on: July 19, 2021

3.6K
An Immature Murine Model of Reversible Unilateral Ureteral Obstruction07:03

An Immature Murine Model of Reversible Unilateral Ureteral Obstruction

Published on: April 4, 2025

216

Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
29
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
42
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
39
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
36
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
25
Urinary Tract Calculi IV: Nutrition Therapy and Prevention01:27

Urinary Tract Calculi IV: Nutrition Therapy and Prevention

Management of renal calculi focuses on effective strategies like tailored nutrition and hydration therapy. Adjusting diet and fluid intake reduces stone formation and recurrence, making these interventions simple yet powerful in kidney stone prevention and management.Understanding Kidney StonesKidney stones form when calcium, oxalate, uric acid, and cystine concentrate and crystallize in urine. Factors contributing to their formation include genetic predisposition, certain medical conditions,...
11