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Cracking the intestinal lymphatic system window utilizing oral delivery vehicles for precise therapy.
Yang-Bao Miao1,2, Tianxing Xu3, Ying Gong4
1Department of Haematology, School of Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, No. 32, West Section 2, First Ring Road, Qingyang District, Chengdu, 610000, China. miaoyangbao@uestc.edu.cn.
Journal of Nanobiotechnology
|August 9, 2023
Summary
Targeting the intestinal lymphatic system (ILS) with specialized drug vehicles can overcome poor oral bioavailability. This strategy enhances drug absorption and therapeutic efficacy for various clinical applications.
Area of Science:
- Pharmacology
- Drug Delivery Systems
- Gastroenterology
Background:
- Oral drug administration is preferred for patient convenience and safety.
- Poor oral bioavailability due to gastrointestinal challenges limits the effectiveness of many drugs.
- The intestinal lymphatic system (ILS) plays a key role in absorbing and transporting lipids and certain medications.
Purpose of the Study:
- To review targeted drug delivery vehicles for the intestinal lymphatic system (ILS).
- To explore strategies for enhancing oral drug bioavailability and targeted delivery via the ILS.
- To discuss the clinical potential of ILS-targeted therapies, including cancer treatment and oral vaccines.
Main Methods:
- Literature review of studies on ILS structure, physiology, and barriers.
- Analysis of various spatially precise drug vehicles designed for ILS targeting.
- Examination of methods to modulate the ILS for improved drug transport.
Main Results:
- The ILS presents unique opportunities and challenges for drug absorption.
- Targeted vehicles can enhance drug bioavailability and reduce first-pass metabolism.
- Strategies exist to open the ILS 'window' for therapeutic interventions.
Conclusions:
- Targeting the intestinal lymphatic system (ILS) with advanced drug vehicles is a promising strategy.
- These approaches can significantly improve oral drug bioavailability and therapeutic outcomes.
- ILS-targeted drug delivery holds potential for significant clinical advancements, particularly in oncology and vaccinology.
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