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Related Experiment Video

Updated: Jul 19, 2025

Cultivation of Heligmosomoides Polygyrus: An Immunomodulatory Nematode Parasite and its Secreted Products
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Helminths revive to survive.

John R Grainger1, Rufus H Daw1

  • 1Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology Medicine and Health, The University of Manchester, Manchester, UK.

The Journal of Experimental Medicine
|August 9, 2023
PubMed
Summary

Helminth parasites, like Heligmosomoides polygyrus barkeri, release factors that alter intestinal stem cells. This modification causes a loss of parasite-expelling secretory cells, aiding helminth persistence.

Area of Science:

  • Immunology
  • Parasitology
  • Gastroenterology

Background:

  • Helminth parasites have evolved sophisticated strategies to evade host immune responses.
  • Understanding these mechanisms is crucial for developing new treatments against parasitic infections.

Purpose of the Study:

  • To investigate how the helminth Heligmosomoides polygyrus barkeri manipulates the host intestinal environment.
  • To identify the specific changes induced in intestinal stem cells by helminth products.

Main Methods:

  • Analysis of intestinal stem cell responses to products from Heligmosomoides polygyrus barkeri.
  • Assessment of epithelial cell type composition in infected versus uninfected hosts.

Main Results:

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  • Products from Heligmosomoides polygyrus barkeri induce a "revival" state in intestinal stem cells.
  • This altered stem cell state is linked to a reduction in secretory cell types responsible for helminth expulsion.

    • Conclusions:

    • Helminth parasites actively reprogram host intestinal stem cells to promote their survival.
    • This immune evasion strategy involves altering epithelial cell differentiation pathways to eliminate host defense mechanisms.