Comparison of circulating lipid profiles, D-dimer and fibrinogen levels between hypertensive patients with and

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Endeshaw Chekol Abebe1, Misganaw Asmamaw Mengstie1, Mohammed Abdu Seid2

  • 1Department of Biochemistry, College of Health Science, Debre Tabor University, Debre Tabor, Ethiopia.

Metabolism Open
|August 10, 2023
PubMed

Insights

Hypertensive patients with stroke show higher lipid, fibrinogen, and D-dimer levels. Total cholesterol, D-dimer, and fibrinogen predict stroke risk in this population, highlighting dyslipidemia and hemostatic activation roles.

Area of Science:

  • Cardiovascular Medicine
  • Neurology
  • Clinical Biochemistry

Background:

  • Stroke is a major cause of death and disability, especially in individuals with hypertension.
  • Hypertension is a significant risk factor for stroke, necessitating research into associated biomarkers.
  • Understanding these biomarkers can aid in stroke prevention and management strategies.

Purpose of the Study:

  • To compare lipid profiles, fibrinogen, and D-dimer levels in hypertensive patients with and without stroke.
  • To identify predictors of stroke among hypertensive patients.

Main Methods:

  • A cross-sectional study involving 115 hypertensive patients (45 with stroke, 70 without).
  • Data collected from November 2022 to January 2023 at Yikatit 12 Hospital Medical College, Ethiopia.
  • Statistical analyses included Chi-square, t-tests, Mann-Whitney U, and multiple logistic regression.

Main Results:

  • Hypertensive patients with stroke had significantly higher levels of Total Cholesterol (TC), LDL-C, D-dimer (D-DI), and fibrinogen compared to those without stroke.
  • TC, D-DI, and fibrinogen were identified as independent predictors of stroke in hypertensive patients.
  • Ischemic stroke patients exhibited higher mean TC, D-DI, and fibrinogen levels than hemorrhagic stroke patients.

Conclusions:

  • Elevated TC, LDL-C, D-DI, and fibrinogen are associated with stroke in hypertensive individuals.
  • TC, D-DI, and fibrinogen are significant predictors of stroke in this patient group.
  • Findings underscore the roles of dyslipidemia and hemostatic activation in stroke development, particularly ischemic stroke.
Abstract

Keywords:
D-dimerFibrinogenHypertensionLipid profilesStroke

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