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Related Experiment Video

Updated: Jul 19, 2025

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Tohoku Medical Megabank Brain Magnetic Resonance Imaging Study: Rationale, Design, and Background.

Makiko Taira1,2,3, Shunji Mugikura1,2,3, Naoko Mori1,2,3

  • 1Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.

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|August 10, 2023
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Summary

The TMM Brain MRI Study collected neuroimaging and neuropsychological data from over 12,000 participants after the Great East Japan Earthquake. This comprehensive database aids research into cognitive function and mental health.

Keywords:
TMM Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study)TMM Community-Based Cohort Study (TMM CommCohort Study)The Tohoku Medical Megabank Brain Magnetic Resonance Imaging Study (TMM Brain MRI Study)cognitive impairmentneuroimagingneuropsychological assessments

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Public Health

Background:

  • The Great East Japan Earthquake (GEJE) and tsunami impacted residents' cognitive function and mental health.
  • Personalized healthcare for mental health and cognitive function requires robust data.

Purpose of the Study:

  • To establish a comprehensive database of neuroimaging and neuropsychological data.
  • To evaluate cognitive function and mental health in GEJE-affected residents.
  • To advance personalized medicine for cognitive and mental health.

Main Methods:

  • Recruited 12,164 participants for baseline survey starting July 2014.
  • Collected multimodal MRI data (T1-weighted, MRA, DTI, pCASL, FLAIR).
  • Assessed neuropsychological status using validated scales (questionnaire and interview-based).

Main Results:

  • Established a large database integrating neuroimaging, psychological, and cognitive data.
  • Data collected from participants in TMM Community-Based Cohort Study and TMM Birth and Three-Generation Cohort Study.
  • Ongoing second survey initiated in October 2019.

Conclusions:

  • The TMM Brain MRI Study created a valuable resource for understanding cognitive impairment and mental health.
  • Combined with existing TMM Biobank genomic and omics data, this database can reveal links between pathology and neuropsychological disorders.