Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Auditory Perception01:17

Auditory Perception

364
The auditory system is essential for sound perception, utilizing various critical structures. When sound waves enter the outer ear, they travel through the ear canal and cause the eardrum to vibrate. These vibrations are then transmitted to the middle ear, where three tiny bones – the malleus, incus, and stapes – amplify the sound. This amplification is crucial, as it ensures that the sound vibrations are strong enough to be conveyed to the inner ear. These vibrations then reach the...
364
Auditory Pathway01:15

Auditory Pathway

5.5K
Auditory pathways constitute the complex neural circuits responsible for transmitting and interpreting auditory information from the peripheral auditory system to the brain. Sound waves are initially captured by the outer ear, funneled through the ear canal, and reach the tympanic membrane (eardrum). These vibrations are transmitted via the middle ear's ossicles to the inner ear's cochlea.
When viewed cross-sectionally, the cochlea reveals the scala vestibuli and scala tympani flanking...
5.5K
Complement System01:27

Complement System

2.4K
The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a...
2.4K
The Cochlea01:13

The Cochlea

45.2K
The cochlea is a coiled structure in the inner ear that contains hair cells—the sensory receptors of the auditory system. Sound waves are transmitted to the cochlea by small bones attached to the eardrum called the ossicles, which vibrate the oval window that leads to the inner ear. This causes fluid in the chambers of the cochlea to move, vibrating the basilar membrane.
45.2K
Hearing01:31

Hearing

52.5K
When we hear a sound, our nervous system is detecting sound waves—pressure waves of mechanical energy traveling through a medium. The frequency of the wave is perceived as pitch, while the amplitude is perceived as loudness.
52.5K
Hair Cells01:22

Hair Cells

40.7K
Hair cells are the sensory receptors of the auditory system—they transduce mechanical sound waves into electrical energy that the nervous system can understand. Hair cells are located in the organ of Corti within the cochlea of the inner ear, between the basilar and tectorial membranes. The actual sensory receptors are called inner hair cells. The outer hair cells serve other functions, such as sound amplification in the cochlea, and are not discussed in detail here.
40.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Alveolus-on-a-chip: A Novel Tool for Modeling Lung Transplant Cold Storage Ischemia/Reperfusion Injury.

Transplantation·2026
Same author

Nebulized mitochondrial transplantation attenuates inflammation and improves graft function in a murine donation after cardiac death lung transplant model.

Transplant immunology·2026
Same author

A Novel Central-Peripheral Interface: The Auditory Nerve Glial Transition Zone Exhibits Enhanced Age-Related Immune and Glial Cell Dysfunction.

bioRxiv : the preprint server for biology·2026
Same author

Use of Machine Learning and 71-Plex Immune Mediator Analysis to Identify Nasal Mucus Biomarkers Associated With Olfactory Loss in Patients with CRSwNP.

American journal of rhinology & allergy·2026
Same author

Evaluation of ventilation at 10 °C as the optimal storage condition for donor lungs in a murine model.

Scientific reports·2026
Same author

Exploring fibroblast activation protein as an early biomarker in chronic lung allograft dysfunction.

The European respiratory journal·2025
Same journal

Mind the gender gap: how defining head trauma increases reporting in women aged 30-50.

Frontiers in neurology·2026
Same journal

Traditional Chinese medicine interventions for post-stroke cognitive impairment: an evidence mapping.

Frontiers in neurology·2026
Same journal

Acupuncture is independently associated with improved recovery in Guillain-Barré syndrome: a prospective observational study.

Frontiers in neurology·2026
Same journal

A convergence of global epidemics: diabetes as a modulator of neurodegenerative and neuro-inflammatory disorders.

Frontiers in neurology·2026
Same journal

Lumbar puncture opening pressure, brain network hub integrity, and delirium in herpes simplex virus encephalitis: a prospective cohort study.

Frontiers in neurology·2026
Same journal

Sleep deprivation: a comprehensive review of multisystem impacts, underlying mechanisms, and emerging interventions.

Frontiers in neurology·2026
See all related articles

Related Experiment Video

Updated: Jul 19, 2025

Morphological and Functional Evaluation of Ribbon Synapses at Specific Frequency Regions of the Mouse Cochlea
09:54

Morphological and Functional Evaluation of Ribbon Synapses at Specific Frequency Regions of the Mouse Cochlea

Published on: May 10, 2019

11.9K

Complement factor B is essential for the proper function of the peripheral auditory system.

LaShardai N Brown1, Jeremy L Barth2, Shabih Jafri1

  • 1Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, United States.

Frontiers in Neurology
|August 10, 2023
PubMed
Summary
This summary is machine-generated.

Complement factor B (fB) deficiency causes progressive hearing impairment in mice. This immune factor is crucial for maintaining auditory nerve myelin and cochlear integrity, highlighting its role in sensorineural hearing loss.

Keywords:
auditory nervecochleacomplement factor Bglial cellhearing lossmacrophagemyelinationstria vascularis

More Related Videos

Semi-Automated Analysis of Peak Amplitude and Latency for Auditory Brainstem Response Waveforms Using R
06:01

Semi-Automated Analysis of Peak Amplitude and Latency for Auditory Brainstem Response Waveforms Using R

Published on: December 9, 2022

2.5K
Data Acquisition and Analysis In Brainstem Evoked Response Audiometry In Mice
08:51

Data Acquisition and Analysis In Brainstem Evoked Response Audiometry In Mice

Published on: May 10, 2019

11.8K

Related Experiment Videos

Last Updated: Jul 19, 2025

Morphological and Functional Evaluation of Ribbon Synapses at Specific Frequency Regions of the Mouse Cochlea
09:54

Morphological and Functional Evaluation of Ribbon Synapses at Specific Frequency Regions of the Mouse Cochlea

Published on: May 10, 2019

11.9K
Semi-Automated Analysis of Peak Amplitude and Latency for Auditory Brainstem Response Waveforms Using R
06:01

Semi-Automated Analysis of Peak Amplitude and Latency for Auditory Brainstem Response Waveforms Using R

Published on: December 9, 2022

2.5K
Data Acquisition and Analysis In Brainstem Evoked Response Audiometry In Mice
08:51

Data Acquisition and Analysis In Brainstem Evoked Response Audiometry In Mice

Published on: May 10, 2019

11.8K

Area of Science:

  • Immunology
  • Neuroscience
  • Otolaryngology

Background:

  • Sensorineural hearing loss involves cochlear cell dysfunction, with unclear immune mechanisms.
  • The complement cascade regulates immune cells and pathogen clearance.
  • Complement factor B (fB) is key to the alternative complement pathway.

Purpose of the Study:

  • To investigate the role of complement factor B (fB) in sensorineural hearing loss.
  • To explore the molecular and cellular changes associated with fB deficiency in the auditory system.

Main Methods:

  • Generated and analyzed mice deficient in functional complement factor B alleles (fB-/-).
  • Performed transcriptomic analysis on auditory nerves.
  • Conducted histological and immunohistochemical investigations of auditory nerves and cochlea.

Main Results:

  • fB-/- mice exhibited progressive hearing impairment.
  • Transcriptomic analysis revealed differential gene expression in auditory nerves, including genes related to extracellular matrix, neural development, and myelin.
  • Histology showed pathological alterations in auditory nerve myelin and the cochlear stria vascularis in fB-/- mice.

Conclusions:

  • Complement factor B (fB) plays a critical role in maintaining auditory nerve myelin sheath integrity.
  • fB is important for the structural integrity of the stria vascularis in the cochlea.
  • Immune signaling pathways, particularly involving fB, are implicated in the pathophysiology of sensorineural hearing loss.