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Serum level of vitamin A in febrile children with and without seizure: A comparative study

Elham Bakhtiari1, Farhad Heydarian2, Fatemeh Azmoudeh2

  • 1Eye Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Heliyon
|August 10, 2023
PubMed

Insights

Serum vitamin A levels did not differ between febrile children and those with febrile seizures (FS). However, in children over 24 months, higher vitamin A levels were observed in the FS group, suggesting a potential role in older children.

Area of Science:

  • Pediatrics
  • Neurology
  • Nutritional Science

Background:

  • The role of vitamins and antioxidants in febrile seizures (FS) is under investigation.
  • Vitamin A's influence on seizures is controversial, with potential to either suppress or provoke them.

Purpose of the Study:

  • To compare serum vitamin A levels in febrile children and children experiencing febrile seizures.
  • To investigate the relationship between vitamin A levels and febrile seizures in different age groups.

Main Methods:

  • A cross-sectional study included 80 children aged 6-60 months, divided into 40 febrile children and 40 with FS.
  • Serum vitamin A levels and other blood parameters were measured from blood samples.

Main Results:

  • No significant difference in serum vitamin A levels was found between the febrile and FS groups overall.
  • In children older than 24 months, serum vitamin A levels were significantly higher in the FS group compared to the febrile group (p=0.01).
  • No significant difference was observed in children under 24 months.

Conclusions:

  • Serum vitamin A levels do not appear to differ between febrile children with and without seizures in general.
  • A surprising finding was the elevated vitamin A level in older children (over 24 months) with FS.
  • Further research is necessary to validate these findings and elucidate the role of vitamin A in pediatric seizures.
Abstract

Keywords:
ChildFeverSeizureVitamin A

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