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Intermittent hypoxia: a call for harmonization in terminology.
Gino S Panza1,2, Johannes Burtscher3, Fei Zhao1,2
1Department of Research and Development, John D. Dingell Veterans Affairs Medical Center, Detroit, Michigan, United States.
Journal of Applied Physiology (Bethesda, Md. : 1985)
|August 10, 2023
Summary
Intermittent hypoxia (IH) shows promise for improving health, but inconsistent terminology creates confusion. Standardizing IH research language is crucial for clarity and advancing its therapeutic potential.
Area of Science:
- Physiology
- Neuroscience
- Cardiovascular Science
Background:
- Intermittent hypoxia (IH) is explored for potential health benefits, including improved cardiovascular and cognitive function.
- A stigma exists around IH due to inconsistent research methods and terminology.
- IH research often overlaps with sleep apnea (SA) pathophysiology, causing confusion.
Purpose of the Study:
- To highlight terminology issues in intermittent hypoxia (IH) research.
- To advocate for harmonized terminology in IH studies.
- To differentiate between IH for SA pathophysiology and IH for physiological enhancement.
Main Methods:
- Perspective paper analyzing IH research terminology.
- Review of studies investigating IH for both negative (SA) and positive (performance enhancement) outcomes.
- Identification of terminological inconsistencies across different research fields.
Main Results:
- Overlapping and unstandardized terminology complicates the understanding of IH protocols and study intentions.
- Different research fields use IH with distinct goals and mechanistic focuses.
- Confusion arises from applying similar terms to both detrimental and beneficial IH exposures.
Conclusions:
- Harmonizing IH terminology is essential for clear scientific communication.
- Standardized language will facilitate a better understanding of IH effects based on protocol and individual responses.
- Clearer terminology will advance research into IH applications for health and performance.
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