Related Experiment Video

Updated: Jul 19, 2025

Author Spotlight: Deciphering Coagulation Disorders in Traumatic Brain Injury Patients
04:56

Author Spotlight: Deciphering Coagulation Disorders in Traumatic Brain Injury Patients

Published on: August 4, 2023

798

Blood Coagulation Disorders Among the Iranian Population: a Systematic Review

Fatemeh Mezginejad, Negin Shokrgozar, Mahnoosh Abbaszade Dibavar

    Clinical Laboratory
    |August 10, 2023
    PubMed

    Insights

    Blood coagulation disorders, particularly Factor XIII (FXIII) deficiency, are prevalent in Iran. The c.562T>C mutation is the most frequent genetic cause identified in this population.

    Area of Science:

    • Hematology
    • Genetics
    • Public Health

    Background:

    • Blood coagulation disorders represent a significant cause of mortality, necessitating focused research.
    • Investigating the prevalence and genetic basis of these disorders in specific populations, like Iran, is crucial for understanding disease burden.

    Approach:

    • A systematic review adhering to PRISMA guidelines was conducted, analyzing data from 1990 to 2019.
    • Searches encompassed major databases (Web of Science, PubMed, Scopus, etc.), including diverse study designs (cross-sectional, cohort, experimental, case-control) without language or gender restrictions.

    Key Points:

    • Factor XIII (FXIII) deficiency is the most common coagulation disorder identified in Southern Iran (599/1,165 individuals).
    • The c.559T>C and c.562T>C mutations were the most frequent genetic variants associated with FXIII deficiency.
    • Factor V (FV) Leiden was the second most common disorder (396/1,165), with the c.1691G>A mutation being its most prevalent genetic cause.

    Conclusions:

    • FXIII deficiency is the most critical coagulation disorder within the Iranian population.
    • The c.562T>C mutation is identified as the most common genetic mutation contributing to coagulation disorders in Iran.
    Abstract

    More Related Videos

    Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro10:25

    Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro

    Published on: March 19, 2016

    9.4K
    Assessment of Plasma Coagulation on Liver Tissue in a Large Animal Model In Vivo06:23

    Assessment of Plasma Coagulation on Liver Tissue in a Large Animal Model In Vivo

    Published on: August 4, 2018

    8.9K

    Related Concept Videos

    Disorders of Hemostasis01:24

    Disorders of Hemostasis

    Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
    Thromboembolic Disorders
    Two factors primarily cause thromboembolic conditions.
    991
    Blood Transfusion01:15

    Blood Transfusion

    Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
    Blood Transfusion Overview
    A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
    613
    Blood Transfusion and Agglutination02:45

    Blood Transfusion and Agglutination

    Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
    History
    The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
    10.9K
    Introduction to Hemostasis01:05

    Introduction to Hemostasis

    Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
    The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
    8.3K
    Blood Types02:20

    Blood Types

    Human blood is classified into different types based on the presence of antigens on the red blood cell's surface and antibodies in the plasma. Proper identification of blood type is essential for successful blood transfusion. The International Society of Blood Transfusion has identified 38 human blood types based on the surface antigens on the red blood cells. The most common types are ABO, Rh, and MNS blood types.
    ABO blood group
    ABO antigens are glycoproteins encoded by genes present on...
    17.9K
    Coagulation01:06

    Coagulation

    Colloidal solids are solid particles suspended in solution. They are usually negatively charged, attracting a compact primary layer of positively charged ions, which attract more counterions to form an electrical double layer. Electrostatic repulsion between the charged double layers prevents the particles from colliding, stabilizing the colloids. These solids are often undesirable because they can contain toxins that are difficult to remove. Coagulation is a technique that helps aggregate and...
    329