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Targeting SARM1 improves autophagic stress-induced axonal neuropathy

Hye Ran Kim1, Hye Jin Lee1, Yewon Jeon2

  • 1Peripheral Neuropathy Research Center (PNRC), Department of Molecular Neuroscience and Translational Biomedical Sciences, Dong-A University College of Medicine, Busan, Republic of Korea.

Autophagy
|August 10, 2023
PubMed
Abstract

Keywords:
Activating transcription factor 3Wallerian degenerationautophagydorsal root gangliondystrophic axonperipheral neuropathy

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Autophagy

Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
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