Related Experiment Video
Updated: Jun 17, 2026
09:21
Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
Published on: January 18, 2018
12.1K
Early neurological deterioration in acute ischemic stroke
Archana Sharma1, Awadh Kishor Pandit2, Biswamohan Mishra1
1Fellowship Neuroendovascular Therapy, Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.
Irish Journal of Medical Science
|August 10, 2023
Summary
Early neurological deterioration (END) in acute ischemic stroke (AIS) patients is linked to poor functional outcomes. High blood glucose and low serum albumin levels are significant risk factors for END.
Area of Science:
- Neurology
- Clinical Medicine
- Stroke Research
Background:
- Early neurological deterioration (END) is defined as clinical worsening within 72 hours of acute ischemic stroke (AIS) onset.
- Understanding END's impact on functional outcomes and identifying associated risk factors is crucial for patient management.
Purpose of the Study:
- To determine the association between END and functional outcomes at 3 months post-AIS.
- To identify risk factors associated with END in AIS patients.
Main Methods:
- A cohort of 190 AIS patients were divided into END and non-END groups.
- Functional outcomes were assessed at 3 months using the modified Rankin Scale (mRS).
- Statistical analysis included univariate and multivariate methods to identify significant prognostic markers.
Main Results:
- 17.8% of AIS patients experienced END.
- END was independently associated with higher admission blood glucose (OR=1.015) and lower serum albumin (OR=0.208).
- Patients with END had significantly poorer functional outcomes (mRS > 2) (94.1%) and higher mortality rates (64.7%) at 3 months.
Conclusions:
- END is associated with poor functional outcomes and increased mortality in AIS patients.
- Elevated blood glucose and low serum albumin are significant risk factors contributing to END.
- Further prospective studies with larger cohorts are recommended to validate these findings.
More Related Videos
05:52Early Pathological and Magnetic Resonance Detection of Cerebral Injury Using a Rat Model of Neonatal Hypoxic Ischemic Encephalopathy
Published on: October 28, 2022
812
07:34Author Spotlight: Establishing a Reliable Distal MCA Occlusion Model in Mice for Stroke Research
Published on: December 15, 2023
2.1K
Related Concept Videos
01:15Ischemic Stroke l: Introduction
Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
01:15Ischemic Stroke ll: Pathophysiology
An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
01:26Transient Ischemic Attack l: Introduction
A transient ischemic attack (TIA) is a brief episode of neurological dysfunction caused by a temporary, focal reduction in cerebral blood flow. Although symptoms resemble those of an ischemic stroke, the interruption in perfusion is short-lived and does not cause permanent infarction. TIAs are clinically important because they often serve as early warning events for future stroke.Mechanisms of Transient Cerebral IschemiaTransient cerebral ischemia may arise through several mechanisms. One...
01:22Dementia l: Introduction
Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...
01:29Hepatic Encephalopathy
DefinitionHepatic encephalopathy is a reversible neurologic syndrome that results from advanced liver dysfunction or portosystemic shunting. It leads to disturbances in cognition, behavior, and motor function due to the brain’s exposure to gut-derived toxins that the liver fails to detoxify.EtiologyThis condition develops either in the setting of acute fulminant hepatitis or progressively during chronic liver disease, such as cirrhosis and portal hypertension. Portosystemic shunting—including...
01:25Secondary Spinal Cord Injury llI: Pathophysiology
Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...