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Metabolic disorders during endogenous Cushing's syndrome: prevalence, associated factors, and outcome after remission

Melika Chihaoui1, Ibtissem Oueslati1, Nadia Khessairi1

  • 11Department of Endocrinology, University Hospital La Rabta, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia.

Endocrine Regulations
|August 10, 2023
PubMed

Insights

Metabolic disorders like obesity and hypertension are common in Cushing's syndrome (CS). Remission of CS significantly improves hypertension and diabetes, but not dyslipidemia, highlighting the need for ongoing management.

Area of Science:

  • Endocrinology
  • Cardiovascular Medicine
  • Metabolic Disorders

Background:

  • Cushing's syndrome (CS) is associated with increased cardiovascular morbidity and mortality.
  • Understanding the prevalence and remission of metabolic disorders in CS is crucial for patient prognosis.

Purpose of the Study:

  • To determine the prevalence of metabolic disorders in patients with Cushing's syndrome.
  • To identify factors associated with these disorders.
  • To assess the remission rates of metabolic disorders after CS remission.

Main Methods:

  • Retrospective study of 75 Cushing's syndrome cases (1987-2018).
  • Data collected from medical files, including clinical and paraclinical information.
  • Analysis of metabolic disorder prevalence and remission rates post-treatment.

Main Results:

  • High prevalence of obesity (52%), hypertension (75%), diabetes (43%), dyslipidemia (83%), and metabolic syndrome (73%) at CS diagnosis.
  • No significant association found between age, gender, BMI, waist circumference, or baseline cortisol and the presence of diabetes, hypertension, or dyslipidemia.
  • After CS remission, remission rates were 58% for hypertension and 76% for diabetes, but only 17% for dyslipidemia.

Conclusions:

  • Metabolic disorders are highly prevalent in Cushing's syndrome.
  • Successful CS remission leads to significant improvement in hypertension and diabetes.
  • Dyslipidemia remission is notably low, indicating a need for continued management even after CS control.

Keywords:
Cushing’s syndromediabetesdyslipidemiahypertensionobesityremission

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