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Related Experiment Video

Updated: May 10, 2026

Bioluminescent Bacterial Imaging In Vivo

Bioluminescent Bacterial Imaging In Vivo

Published on: November 4, 2012

Engineered bacteria detect tumor DNA.

Robert M Cooper¹, Josephine A Wright², Jia Q Ng³

¹Synthetic Biology Institute, University of California, San Diego, La Jolla, CA 92093, USA.

Science (New York, N.Y.)

|August 10, 2023

Summary

This summary is machine-generated.

Researchers engineered bacteria to detect colorectal cancer (CRC) DNA. This cellular assay for targeted, CRISPR-discriminated horizontal gene transfer (CATCH) enables biodetection of specific cell-free DNA from tumors.

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Bioluminescent Bacterial Imaging In Vivo

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Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

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Area of Science:

Synthetic biology
Microbial engineering
Genomics

Background:

Cellular biosensors are advanced tools for disease detection.
Current biosensors lack the ability to detect specific extracellular DNA sequences and mutations.

Purpose of the Study:

To engineer a biosensor capable of detecting donor DNA from colorectal cancer (CRC) cells.
To validate the biosensor's functionality in vitro and in vivo for CRC detection.

Main Methods:

Engineering naturally competent *Acinetobacter baylyi* as a biosensor.
In vitro coculture assays to characterize biosensor function.
In vivo validation using a mouse model of CRC with sensor bacteria.

Main Results:

Successful engineering of *Acinetobacter baylyi* to detect CRC cell, organoid, and tumor DNA.
Demonstrated horizontal gene transfer from colorectal tumors to sensor bacteria in vivo.
Validated the CATCH assay for detecting specific cell-free DNA.

Conclusions:

The CATCH assay provides a novel method for biodetection of specific cell-free DNA.
Engineered bacteria can serve as effective biosensors for detecting cancer-derived DNA.
This approach has potential applications in cancer diagnostics and monitoring.