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Related Concept Videos

Epigenetic Regulation01:46

Epigenetic Regulation

31.1K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
31.1K
Euchromatin01:01

Euchromatin

7.0K
The extent of chromatin compaction can be studied by staining chromatin using specific DNA binding dyes. Under the microscope, the dense-compacted regions take up more dye, appearing darker, while the less-compact areas take up less dye and appear lighter. Based on the compaction level, chromatins are classified into two primary forms – euchromatin and heterochromatin.
Euchromatin is the less dense region of the chromatin and stains lighter. Euchromatin contains histone H3 extensively...
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Heterochromatin02:38

Heterochromatin

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The extent of chromatin compaction can be studied by staining chromatin using specific DNA binding dyes. Under the microscope, the dense-compacted regions that take up more dye are called heterochromatin. Heterochromatin is further classified into two forms – constitutive heterochromatin and facultative heterochromatin.
Constitutive heterochromatin: It is a highly compact region of chromatin that is mostly concentrated in the centromere and telomere. Unlike euchromatin, the amino acid at...
13.9K
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

34.7K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
34.7K
Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

6.3K
Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
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Histone Modification02:32

Histone Modification

13.4K
The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone...
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Related Experiment Video

Updated: Jul 19, 2025

Immunostaining for DNA Modifications: Computational Analysis of Confocal Images
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Immunostaining for DNA Modifications: Computational Analysis of Confocal Images

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A mammalian DNA methylation landscape.

Alex de Mendoza1

  • 1School of Biological and Behavioural Sciences, Queen Mary University of London, London, UK.

Science (New York, N.Y.)
|August 10, 2023
PubMed
Summary

This study explores the diverse lifespans across 348 mammalian species. Findings shed light on the evolutionary factors influencing longevity in mammals.

Area of Science:

  • Zoology
  • Evolutionary Biology

Background:

  • Mammalian lifespans exhibit remarkable variation.
  • Understanding this diversity is key to comprehending evolutionary adaptations.

Purpose of the Study:

  • To investigate the factors contributing to the wide range of mammalian lifespans.
  • To provide insights into the evolutionary pressures shaping longevity.

Main Methods:

  • Analysis of lifespan data from 348 mammalian species.
  • Comparative analysis across different mammalian groups.

Main Results:

  • Significant variation in maximum and average lifespans observed.
  • Identification of potential correlations between lifespan and factors like body size and metabolic rate.

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Enhanced Reduced Representation Bisulfite Sequencing for Assessment of DNA Methylation at Base Pair Resolution

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Methyl-binding DNA capture Sequencing for Patient Tissues
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Methyl-binding DNA capture Sequencing for Patient Tissues

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Related Experiment Videos

Last Updated: Jul 19, 2025

Immunostaining for DNA Modifications: Computational Analysis of Confocal Images
09:42

Immunostaining for DNA Modifications: Computational Analysis of Confocal Images

Published on: September 7, 2017

9.8K
Enhanced Reduced Representation Bisulfite Sequencing for Assessment of DNA Methylation at Base Pair Resolution
13:47

Enhanced Reduced Representation Bisulfite Sequencing for Assessment of DNA Methylation at Base Pair Resolution

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Methyl-binding DNA capture Sequencing for Patient Tissues
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Conclusions:

  • Mammalian lifespan is a complex trait influenced by multiple evolutionary factors.
  • Further research can elucidate the specific mechanisms driving longevity diversity.